Publication
Agranulocytosis and liver damage associated with pyrazinobutazone with evidence for an immunological mechanism
| dc.contributor.author | Maria, Vasco A. | |
| dc.contributor.author | Silva, J. A. da | |
| dc.contributor.author | Victorino, Rui M. | |
| dc.date.accessioned | 2021-01-20T16:40:01Z | |
| dc.date.available | 2021-01-20T16:40:01Z | |
| dc.date.issued | 1989-11 | |
| dc.description | Copyright © 1989 by The Journal of Rheumatology Publishing Co. Ltd. | pt_PT |
| dc.description.abstract | Agranulocytosis and liver injury is described in a patient with Reiter's syndrome of 3 years duration who received pyrazinobutazone for 6 weeks before the development of the clinical picture reported. Other causes of agranulocytosis and hepatic damage were excluded and a lymphocyte transformation test to the drug revealed significant lymphocyte proliferation in response to the drug. This suggests a hypersensitivity reaction as the mechanism for this previously unrecognized association of adverse effects to pyrazinobutazone. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | J Rheumatol. 1989 Nov;16(11):1484-1485 | pt_PT |
| dc.identifier.eissn | 1499-2752 | |
| dc.identifier.issn | 0315-162X | |
| dc.identifier.uri | http://hdl.handle.net/10451/45882 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | The Journal of Rheumatology Publishing Co. Ltd. | pt_PT |
| dc.relation.publisherversion | https://www.jrheum.org/ | pt_PT |
| dc.subject | Pyrazinobutazone | pt_PT |
| dc.subject | Reiter's syndrome | pt_PT |
| dc.subject | Agranulocytosis | pt_PT |
| dc.subject | Hepatitis | pt_PT |
| dc.subject | Drug hypersensitivity | pt_PT |
| dc.title | Agranulocytosis and liver damage associated with pyrazinobutazone with evidence for an immunological mechanism | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 1485 | pt_PT |
| oaire.citation.issue | 11 | pt_PT |
| oaire.citation.startPage | 1484 | pt_PT |
| oaire.citation.title | The Journal of Rheumatology | pt_PT |
| oaire.citation.volume | 16 | pt_PT |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | article | pt_PT |
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