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Antimicrobial resistance and virulence profiles of Enterobacterales isolated from two-finger and three-finger sloths (Choloepus hoffmanni and Bradypus variegatus) of Costa Rica

2022-03-11Journal article Open access
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dc.contributor.authorFernandes, Matilde
dc.contributor.authorCarneiro, Carla
dc.contributor.authorVillada Rosales, Ana Maria
dc.contributor.authorGrilo, Miguel
dc.contributor.authorRamiro, Yolanda
dc.contributor.authorCunha, Eva
dc.contributor.authorNunes, Telmo
dc.contributor.authorTavares, Luis
dc.contributor.authorSandi, Janet
dc.contributor.authorOliveira, Manuela
dc.date.accessioned2022-04-22T23:19:25Z
dc.date.available2022-04-22T23:19:25Z
dc.date.issued2022-03-11
dc.descriptionResearch Areas: Science & Technology ; Other Topicspt_PT
dc.description.abstractBackground: Wildlife has been recently recognized as an environmental reservoir for antimicrobial resistance (AMR). However, less information on this topic is available in animals released back into the wild after rehabilitation in wildlife facilities, compared with studies performed exclusively in captive or free-ranging wildlife. This study aimed to evaluate the potential influence of captivity and/or treatment while in captivity of wild sloths on the AMR and virulence profiles of sloths’ Enterobacterales. Methods: Oral and rectal swab samples were collected from 39 two-finger (Choloepus hoffmanni) and three-finger sloths (Bradypus variegatus) of Costa Rica (n = 78) and analyzed using conventional bacteriological techniques. A generalized linear mixed model was applied to estimate the isolates’ multiple antimicrobial resistance and virulence indices as a function of animal status. Results: A considerable level of resistance was detected, especially for Citrobacter youngae and Escherichia coli, with 17.5% of isolates classified as multidrug-resistant. Virulence indices of isolates from rehabilitated sloths were significantly higher than the ones from sloths being hand-reared for shorter periods. Conclusions: To our knowledge, this is the first description of sloths’ antimicrobial resistant Enterobacterales, suggesting that sloths’ rehabilitation and consequent exposure to humans, may promote the selection of bacteria with higher virulence. Ultimately, these bacteria may represent a threat to human and animal health due to their zoonotic potential and AMR and virulence profiles.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFernandes M, Nóbrega Carneiro C, Villada Rosales AM, Grilo M, Ramiro Y, Cunha E, Nunes T, Tavares L, Sandi J, Oliveira M. 2022. Antimicrobial resistance and virulence profiles of Enterobacterales isolated from two-finger and three-finger sloths (Choloepus hoffmanni and Bradypus variegatus) of Costa Rica. PeerJ, 10:e12911. Doi 10.7717/peerj.12911pt_PT
dc.identifier.doi10.7717/peerj.12911pt_PT
dc.identifier.issn2167-8359
dc.identifier.urihttp://hdl.handle.net/10400.5/24147
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPEERJ INCpt_PT
dc.relationCentre for Interdisciplinary Research in Animal Health
dc.relation.publisherversionhttps://peerj.com/articles/12911/#pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntimicrobial resistancept_PT
dc.subjectBacterial virulence factorspt_PT
dc.subjectWildlife bacteriapt_PT
dc.subjectOne healthpt_PT
dc.subjectCholoepus hoffmannipt_PT
dc.subjectBradypus variegatuspt_PT
dc.titleAntimicrobial resistance and virulence profiles of Enterobacterales isolated from two-finger and three-finger sloths (Choloepus hoffmanni and Bradypus variegatus) of Costa Ricapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Interdisciplinary Research in Animal Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00276%2F2020/PT
oaire.citation.conferencePlaceLondon, Englandpt_PT
oaire.citation.titlePeerJpt_PT
oaire.citation.volume10:12911pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameNóbrega
person.familyNameGrilo
person.familyNameGonçalves da Cunha
person.familyNameLandeiro Raposo Pina Nunes
person.familyNameMorgado Tavares
person.familyNameOliveira
person.givenNameCarla
person.givenNameMiguel
person.givenNameEva Sofia
person.givenNameTelmo Renato
person.givenNameLuis Manuel
person.givenNameManuela
person.identifier.ciencia-id4B17-DF6F-1A51
person.identifier.ciencia-id9811-7B6B-E2B9
person.identifier.ciencia-id2C1A-E281-3E6F
person.identifier.ciencia-id9011-18C6-482D
person.identifier.ciencia-idBE1E-2B3B-92D2
person.identifier.orcid0000-0002-3330-9720
person.identifier.orcid0000-0001-7364-821X
person.identifier.orcid0000-0002-5641-4400
person.identifier.orcid0000-0003-4388-5366
person.identifier.orcid0000-0001-8671-6285
person.identifier.orcid0000-0002-3910-1525
person.identifier.scopus-author-id57195729611
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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