Logo do repositório
 
Publicação

Osteoblasts and bone formation

2007Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorCaetano-Lopes, Joana
dc.contributor.authorCanhao, Helena
dc.contributor.authorFonseca, João Eurico
dc.date.accessioned2021-03-11T16:24:12Z
dc.date.available2021-03-11T16:24:12Z
dc.date.issued2007
dc.description© 2007 Sociedade Portuguesa de Reumatologiapt_PT
dc.description.abstractBone is constantly being remodelled in a dynamic process where osteoblasts are responsible for bone formation and osteoclasts for its resorption. Osteoblasts are specialized mesenchymal cells that undergo a process of maturation where genes like core-binding factor α1 (Cbfa1) and osterix (Osx) play a very important role. Moreover, it was found recently that the Wnt/β-catenin pathway plays a part on osteoblast differentiation and proliferation. In fact, mutations on some of the proteins involved in this pathway, like the low-density lipoprotein receptor related protein 5/6 (LRP5/6), lead to bone diseases. Osteoblasts have also a role in the regulation of bone resorption through receptor activator of nuclear factor-κB (RANK) ligand (RANKL), that links to its receptor, RANK, on the surface of pre-osteoclast cells, inducing their differentiation and fusion. On the other hand, osteoblasts secrete a soluble decoy receptor (osteoprotegerin, OPG) that blocks RANK/RANKL interaction by binding to RANKL and, thus, prevents osteoclast differentiation and activation. Therefore, the balance between RANKL and OPG determines the formation and activity of osteoclasts. Another factor that influences bone mass is leptin, a hormone produced by adipocytes that have a dual effect. It can act through the central nervous system and diminish osteoblasts activity, or can have an osteogenic effect by binding directly to its receptors on the surface of osteoblast cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationActa Reumatol Port. 2007 Apr-Jun;32(2):103-110pt_PT
dc.identifier.issn0303-464X
dc.identifier.urihttp://hdl.handle.net/10451/46797
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociedade Portuguesa de Reumatologiapt_PT
dc.relation.publisherversionhttp://www.actareumatologica.pt/pt_PT
dc.subjectOsteoblastspt_PT
dc.subjectBone Formationpt_PT
dc.subjectWnt/β-catenin signallingpt_PT
dc.subjectLeptinpt_PT
dc.subjectCbfa1pt_PT
dc.titleOsteoblasts and bone formationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage110pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage103pt_PT
oaire.citation.titleActa Reumatológica Portuguesapt_PT
oaire.citation.volume32pt_PT
person.familyNameCaetano-Lopes
person.familyNameCanhao
person.familyNameFonseca
person.givenNameJoana
person.givenNameHelena
person.givenNameJoão
person.identifier.ciencia-idF310-B85D-57C7
person.identifier.orcid0000-0003-0310-4641
person.identifier.orcid0000-0002-3239-2809
person.identifier.orcid0000-0003-1432-3671
person.identifier.scopus-author-id16300521000
person.identifier.scopus-author-id6602393492
person.identifier.scopus-author-id7101983519
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication07046d91-681a-40b6-ba4f-077892c65885
relation.isAuthorOfPublication48f3be39-37f9-44de-9c7e-22e49a89efe5
relation.isAuthorOfPublication1772dc12-7c55-4c76-ae2d-c23270172480
relation.isAuthorOfPublication.latestForDiscovery07046d91-681a-40b6-ba4f-077892c65885

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Osteoblasts_formation.pdf
Tamanho:
130.84 KB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

FM-CUR-Artigos em Revistas Nacionais
IMM - Artigos em Revistas Nacionais