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Executive functions and insight in OCD : a comparative study

2021Artigo científico Acesso aberto
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dc.contributor.authorManarte, Lucas
dc.contributor.authorAndrade, António R.
dc.contributor.authorRosário, Linete do
dc.contributor.authorSampaio, Daniel
dc.contributor.authorFigueira, Maria Luísa
dc.contributor.authorMorgado, Pedro
dc.contributor.authorSahakian, Barbara J.
dc.date.accessioned2021-05-19T14:32:53Z
dc.date.available2021-05-19T14:32:53Z
dc.date.issued2021
dc.description© The Author(s). 2021. This article is licensed under a Creative Commons Attribution 4.0 International License.pt_PT
dc.description.abstractBackground: Around 25 to 30% of patients with obsessive-compulsive disorder (OCD) do not respond to treatment. These patients have the longest duration of disease and the worst prognosis. Following years of research on this topic, insight has emerged as a potential explanation for this therapeutic resistance. Therefore, it has become important to characterize OCD patients with poor insight. Few studies have focused on the neuropsychological and cognitive characteristics of these patients. Methods: To help fill this gap, we divided 57 patients into two groups, one with good insight and the other with poor insight, assessed their neuropsychological functions-through a Rey's figure test, a California verbal learning test, a Toulouse-Piéron test and a Wisconsin Card Sorting Test (WCST)-and compared the results with those of a paired control group. Results: The statistical analysis, with a significance level of 95%, revealed differences in the executive function tests, and particularly in the WCST (p ≤ 0.001) and trail-making-test (TMT A/B) (p = 0.002). Conclusions: These differences suggest that the neuropsychological profile of poor-insight patients is different from their good-insight counterparts, emphasize the role played by the executive functions in insight and highlights the need for more accurate neurocognitive research and treatment.pt_PT
dc.description.sponsorshipThe second author wishes to acknowledge the support of the Foundation for Science and Technology (FCT), through IDMEC, under LAETA, project UIDB/50022/2020.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMC Psychiatry. 2021 Apr 29;21(1):216pt_PT
dc.identifier.doi10.1186/s12888-021-03227-wpt_PT
dc.identifier.eissn1471-244X
dc.identifier.urihttp://hdl.handle.net/10451/48013
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relationAssociate Laboratory of Energy, Transports and Aeronautics
dc.relation.publisherversionhttps://bmcpsychiatry.biomedcentral.com/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectExecutive functionspt_PT
dc.subjectInsightpt_PT
dc.subjectObsessive-compulsive disorderpt_PT
dc.subjectTrail-making testpt_PT
dc.subjectVerbal memorypt_PT
dc.subjectWisconsin card sorting Testpt_PT
dc.titleExecutive functions and insight in OCD : a comparative studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociate Laboratory of Energy, Transports and Aeronautics
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50022%2F2020/PT
oaire.citation.issue1pt_PT
oaire.citation.titleBMC Psychiatrypt_PT
oaire.citation.volume21pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameManarte
person.familyNameSampaio
person.familyNameFigueira
person.givenNameLucas
person.givenNameDaniel
person.givenNameMaria Luisa
person.identifier.ciencia-id9A14-43A4-EDC4
person.identifier.ciencia-id4018-A916-81EC
person.identifier.orcid0000-0002-9771-8179
person.identifier.orcid0000-0001-8049-7536
person.identifier.orcid0000-0002-7921-5375
person.identifier.scopus-author-id7004088066
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationfa558963-f90b-4ee6-8c6a-8871e5f3847e
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