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Antimicrobial resistance in commensal Staphylococcus aureus from wild ungulates is driven by agricultural land cover and livestock farming

2022-06Journal article Open access
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dc.contributor.authorRamos, Beatriz
dc.contributor.authorRosalino, L. M.
dc.contributor.authorPalmeira, Josman D.
dc.contributor.authorTorres, Rita T.
dc.contributor.authorCunha, Mónica V.
dc.date.accessioned2022-03-10T18:39:35Z
dc.date.available2024-06-01T00:30:40Z
dc.date.issued2022-06
dc.description.abstractStaphylococcus aureus is a human pathobiont (i.e., a commensal microorganism that is potentially pathogenic under certain conditions), a nosocomial pathogen and a leading cause of morbidity and mortality in humans. S. aureus is also a commensal and pathogen of companion animals and livestock. The dissemination of antimicrobial resistant (AMR) S. aureus, particularly methicillin-resistant (MRSA), has been associated to its ability for establishing new reservoirs, but limited attention has been devoted to the role of the environment. To fill this gap, we aimed to characterize animal carrier status, AMR phenotypes, predominant clonal lineages and their relationship with clinical and food-chain settings, as well as to find predictors of AMR occurrence. Nasal swabs (n = 254) from wild boar (n = 177), red deer (n = 54) and fallow deer (n = 23) hunted in Portugal, during the season 2019/2020, yielded an overall carrier proportion of 35.8%, ranging from 53.7% for red deer and 32.2% for wild boar to 21.7% for fallow deer. MRSA from wild boar and phenotypically linezolid-resistant S. aureus from wild boar and red deer were isolated, indicating that resistance to antimicrobials restricted to clinical practice also occurs in wildlife. The most prevalent genotypes were t11502/ST2678 (29.6%) and t12939/ST2678 (9.4%), previously reported in wild boar from Spain. Clonal lineages reported in humans and livestock, like CC1, CC5 or CC8 (19.1%) and ST425, CC133 or CC398 (23.5%), respectively, were also found. The sequence type ST544, previously restricted to humans, is described in wildlife for the first time. We also identified that land use (agricultural land cover), human driven disturbance (swine abundance) and host-related factors (sex) determine resistance occurrence. These findings suggest that antibiotics used in clinical settings, agriculture and livestock farming, spill over to wildlife, leading to AMR emergence, with potential biological, ecological, and human health effects. This work is one of the most comprehensive surveys in Europe of S. aureus occurrence and determinants among widely distributed wild ungulates.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationBeatriz Ramos, Luís Miguel Rosalino, Josman D. Palmeira, Rita T. Torres, Mónica V. Cunha, Antimicrobial resistance in commensal Staphylococcus aureus from wild ungulates is driven by agricultural land cover and livestock farming, Environmental Pollution, Volume 303, 2022, 119116, ISSN 0269-7491, https://doi.org/10.1016/j.envpol.2022.119116.pt_PT
dc.identifier.doi10.1016/j.envpol.2022.119116pt_PT
dc.identifier.urihttp://hdl.handle.net/10451/51683
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPOCI-01-0145-FEDER-030310pt_PT
dc.relationFCT UIDB/00329/2020pt_PT
dc.relationFCT DFA/BD/7777/ 2020pt_PT
dc.relationPOCI-01-0145- FEDER-028204pt_PT
dc.relationFCT UIDB/04046/2020pt_PT
dc.relationFCT UIDP/50017/2020 + UIDB/50017/2020pt_PT
dc.titleAntimicrobial resistance in commensal Staphylococcus aureus from wild ungulates is driven by agricultural land cover and livestock farmingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage119116pt_PT
oaire.citation.titleEnvironmental Pollutionpt_PT
oaire.citation.volume303pt_PT
person.familyNameRosalino
person.familyNameCunha
person.givenNameLuís Miguel
person.givenNameMonica V.
person.identifierB-9406-2009
person.identifier348477
person.identifier.ciencia-id9D1D-B42A-286C
person.identifier.ciencia-id5616-E715-2F31
person.identifier.orcid0000-0003-4186-7332
person.identifier.orcid0000-0003-0401-0276
person.identifier.ridD-5544-2011
person.identifier.scopus-author-id6506527252
person.identifier.scopus-author-id7102711216
rcaap.embargofctO tipo de licença envolvido com a editora Elsevier para esta revista, não envolvendo pagamento (APC), apenas permite acesso em repositório público do formato 'aceite' (i.e não editado e paginado pela editora) após período de embargo de 24 meses após a data da sua publicação final.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication99ace499-6e09-4d61-ac99-f5d815977526
relation.isAuthorOfPublicationa1b365bb-7421-4bf5-9cde-62b74c170e69
relation.isAuthorOfPublication.latestForDiscoverya1b365bb-7421-4bf5-9cde-62b74c170e69

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