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Phytosterols in milk as a depressor of plasma cholesterol levels : experimental evidence with hypercholesterolemic Portuguese subjects
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Resumo(s)
Plant sterols have been reported to decrease plasma concentrations of cholesterol without any side effects. To evaluate the effects on plasma cholesterol concentrations and the hemorheological parameters, we performed a study with hypercholesterolemic patients (n=19) treated with phytosterol-enriched milk (2 g/day). Hypercholesterolemic patients (n=15) of matched age drinking equal type of milk but without phytosterols were used as control group. Concentrations of total cholesterol, HDL-C, LDL-C and hemorheological parameters were measured in the beginning, after 15 and 30 days of milk intake. After 15 days of beverage intake, hypercholesterolemic subjects treated with phytosterol-enriched milk showed a significant decrease in plasma concentrations of total cholesterol and LDL-C by 9.62% (p<0.05) and 12.20% (p<0.05), respectively. After 30 days, a little increase in the total cholesterol and LDL-C concentrations were observed. In the hypercholesterolemic control group there were nonsignificant changes between plasma concentrations of total cholesterol, HDL-C and LDL-C during the study. The evaluation of plasma viscosity and erythrocyte aggregation shows no changes statistically significant during the study for both groups studied. The results obtained during the study show a positive effect with the phytosterol-enriched milk as plasma cholesterol-lowering as combined treatment for hypercholesterolemia.
Descrição
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Palavras-chave
Hypercholesterolemia Phytosterols LDL-C HDL-C Functional food Plasma viscosity Erythrocyte aggregation
Contexto Educativo
Citação
Clinical Hemorheology and Microcirculation, vol. 35, no. 1-2, pp. 251-255, 2006