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In the flow of molecular miniaturized fungal diagnosis

2024Journal article Restricted access
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dc.contributor.authorZolotareva, Maria
dc.contributor.authorCascalheira, Francisco
dc.contributor.authorCaneiras, Catia
dc.contributor.authorBárbara, Cristina
dc.contributor.authorCaetano, Diogo Miguel
dc.contributor.authorTeixeira, Miguel Cacho
dc.date.accessioned2025-01-21T12:10:15Z
dc.date.available2025-01-21T12:10:15Z
dc.date.issued2024
dc.description© 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologiespt_PT
dc.description.abstractThe diagnosis of fungal infections presents several challenges and limitations, stemming from the similarities in symptomatology, diversity of underlying pathogenic species, complexity of fungal biology, and scarcity of rapid, affordable, and point-of-care approaches. In this review, we assess technological advances enabling the conversion of cutting-edge laboratory molecular diagnostic methods to cost-effective microfluidic devices. The most promising strategies toward the design of DNA sequence-based fungal diagnostic systems, capable of capturing and deciphering the highly informative DNA of the pathogen and adapted for resource-limited settings, are discussed, bridging fungal biology, molecular genetics, microfluidics, and biosensors.pt_PT
dc.description.sponsorshipThis work was supported by National Funds supported by Fundação para a Ciência e a Tecnologia (FCT) as part of projects UIDB/04565/2020 and UIDP/04565/2020 of the Research Unit Institute for Bioengineering and Biosciences (iBB), and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy (i4HB), as well as through the financing of pluriannual BASE INESC MN (UID/05367/2020) and PROGRAMATICO (UIDP/05367/2020). Funding was also received from EIT Health Innovation Call Bactometer (RIS_innovation-068 and MORE4MEDICAL ECSEL/0007/2019) and Health from Portugal (HfPT) (02/C05-i01.01/2022.PC644937233-00000047 and UNLOOC HORIZON-KDT-JU-2023-1-IA-Topic-1).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTrends Biotechnol. 2024 Dec;42(12):1628-1643pt_PT
dc.identifier.doi10.1016/j.tibtech.2024.06.010pt_PT
dc.identifier.eissn1879-3096
dc.identifier.issn0167-7799
dc.identifier.urihttp://hdl.handle.net/10400.5/97392
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMORE4MEDICAL ECSEL/0007/2019pt_PT
dc.relationInstitute for Bioengineering and Biosciences
dc.relationInstitute for Bioengineering and Biosciences
dc.relationInstitute for Health and Bioeconomy
dc.relationINESC Microsystems and Nanotechnologies
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/trends-in-biotechnologypt_PT
dc.subjectBiosensorspt_PT
dc.subjectFungal infectionpt_PT
dc.subjectMicrofluidicspt_PT
dc.subjectMolecular diagnosispt_PT
dc.titleIn the flow of molecular miniaturized fungal diagnosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardTitleInstitute for Health and Bioeconomy
oaire.awardTitleINESC Microsystems and Nanotechnologies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04565%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04565%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0140%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05367%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F05367%2F2020/PT
oaire.citation.endPage1643pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage1628pt_PT
oaire.citation.titleTrends in Biotechnologypt_PT
oaire.citation.volume42pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Programático
person.familyNameCaneiras
person.familyNameBárbara
person.givenNameCatia
person.givenNameCristina
person.identifier1330713
person.identifier.ciencia-id5217-449F-3B4F
person.identifier.ciencia-id171F-DE21-B23B
person.identifier.orcid0000-0002-3735-8554
person.identifier.orcid0000-0003-0915-4105
person.identifier.scopus-author-id6701574502
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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