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Computer simulations reveal complex distribution of haemodynamic forces in a mouse retina model of angiogenesis

2013-11-07Artigo científico Acesso aberto
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dc.contributor.authorBernabeu, Miguel O.
dc.contributor.authorJones, Martin
dc.contributor.authorNielsen, Jens H.
dc.contributor.authorKrüger, Timm
dc.contributor.authorNash, Rupert W.
dc.contributor.authorGroen, Derek
dc.contributor.authorSchmieschek, Sebastian
dc.contributor.authorHetherington, James
dc.contributor.authorGerhardt, Holger
dc.contributor.authorFranco, Claudio
dc.contributor.authorCoveney, Peter V.
dc.date.accessioned2022-02-16T14:26:54Z
dc.date.available2022-02-16T14:26:54Z
dc.date.issued2013-11-07
dc.description© 2014 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.pt_PT
dc.description.abstractThere is currently limited understanding of the role played by haemodynamic forces on the processes governing vascular development. One of many obstacles to be overcome is being able to measure those forces, at the required resolution level, on vessels only a few micrometres thick. In this paper, we present an in silico method for the computation of the haemodynamic forces experienced by murine retinal vasculature (a widely used vascular development animal model) beyond what is measurable experimentally. Our results show that it is possible to reconstruct high-resolution three-dimensional geometrical models directly from samples of retinal vasculature and that the lattice-Boltzmann algorithm can be used to obtain accurate estimates of the haemodynamics in these domains. We generate flow models from samples obtained at postnatal days (P) 5 and 6. Our simulations show important differences between the flow patterns recovered in both cases, including observations of regression occurring in areas where wall shear stress (WSS) gradients exist. We propose two possible mechanisms to account for the observed increase in velocity and WSS between P5 and P6: (i) the measured reduction in typical vessel diameter between both time points and (ii) the reduction in network density triggered by the pruning process. The methodology developed herein is applicable to other biomedical domains where microvasculature can be imaged but experimental flow measurements are unavailable or difficult to obtain.pt_PT
dc.description.sponsorshipThis work was supported by: Cancer Research UK; the Lister Institute of Preventive Medicine; the Leducq Transatlantic Network ARTEMIS; the UK-Israel Initiative BIRAX; EPSRC grants ‘2020 Science’ (http://www.2020science.net/, EP/I017909/1), ‘Large Scale Lattice Boltzmann for Biocolloidal Systems’ (EP/I034602/1) and ‘UK Consortium on Mesoscale Engineering Sciences (UKCOMES)’ (EP/L00030X/1); and the EC-FP7 projects CRESTA (http://www.cresta-project.eu/, grant no. 287703) and MAPPER (http://www.mapper-project.eu/, grant no. 261507). C.A.F. is supported by a Marie Curie Post-doctoral Fellowship of the European Commission FP7 People framework. This work made use of the HECToR and ARCHER UK National Supercomputing Services (http://www.archer.ac.uk) (under EPSRC grants EP/I017909/1 and EP/L00030X/1).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ R Soc Interface. 2014 Oct 6;11(99):20140543pt_PT
dc.identifier.doi10.1098/rsif.2014.0543pt_PT
dc.identifier.eissn1742-5662
dc.identifier.issn1742-5689
dc.identifier.urihttp://hdl.handle.net/10451/51348
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherThe Royal Societypt_PT
dc.relationCollaborative Research into Exascale Systemware, Tools and Applications
dc.relationMultiscale Applications on European e-Infrastructures
dc.relation.publisherversionhttps://royalsocietypublishing.org/journal/rsifpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAngiogenesispt_PT
dc.subjectBlood flowpt_PT
dc.subjectLattice-Boltzmannpt_PT
dc.subjectMousept_PT
dc.subjectRetinapt_PT
dc.subjectShear stresspt_PT
dc.titleComputer simulations reveal complex distribution of haemodynamic forces in a mouse retina model of angiogenesispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumber287703
oaire.awardNumber261507
oaire.awardTitleCollaborative Research into Exascale Systemware, Tools and Applications
oaire.awardTitleMultiscale Applications on European e-Infrastructures
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/287703/EU
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/261507/EU
oaire.citation.issue99pt_PT
oaire.citation.titleJournal of the Royal Society, Interfacept_PT
oaire.citation.volume11pt_PT
oaire.fundingStreamFP7
oaire.fundingStreamFP7
person.familyNameFranco
person.givenNameClaudio
person.identifierD-8117-2015
person.identifier.ciencia-idF012-B7D6-AE72
person.identifier.orcid0000-0002-2861-3883
person.identifier.scopus-author-id24280736600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication633fb0a6-1f81-4d35-98ca-b4cfd838d81e
relation.isAuthorOfPublication.latestForDiscovery633fb0a6-1f81-4d35-98ca-b4cfd838d81e
relation.isProjectOfPublicationc7d797b1-5796-47cd-b972-8a39fce92d49
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relation.isProjectOfPublication.latestForDiscoveryc7d797b1-5796-47cd-b972-8a39fce92d49

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