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Micro RNAs in Tfh regulation : small molecules with a big impact
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Resumo(s)
ABSTRACT - The germinal center (GC) reactions are critical for the production of high-affinity antibodies that comprise the protective humoral response elicited by infection or vaccination. GCs are initiated through the interaction of B cells with T follicular helper (Tfh) cells.
While the transcriptional regulation of Tfh differentiation has been studied in great detail,
the impact of micro RNAs (miRNAs) on Tfh development and stability has been harder to
address. It was previously shown that a complete deletion of miRNAs biogenesis prevents
Tfh differentiation. In this issue of the European Journal of Immunology [Eur. J. Immunol.
2021. 51: 408-413], Zeiträg et al. use an inducible gene deletion approach to reveal that
miRNAs are also required for the maintenance of Tfh cells induced following viral infection in mice. These results provide new clues to the regulation of GC responses through
Tfh and T follicular regulatory cells.
Descrição
Research Areas: Immunology
Palavras-chave
Micro RNAs T follicular helper cells T follicular regulatory cells Germinal center
Contexto Educativo
Citação
Basto AP, Graça L. 2021. Micro RNAs in Tfh regulation : small molecules with a big impact. European Journal of Immunology. 51(2):p. 292-295
Editora
Wiley