Publication
Mitochondrial quality control pathways: PINK1 acts as a gatekeeper
| dc.contributor.author | Leites, Elvira | |
| dc.contributor.author | Morais, Vanessa A. | |
| dc.date.accessioned | 2021-03-26T12:45:56Z | |
| dc.date.available | 2021-03-26T12:45:56Z | |
| dc.date.issued | 2018 | |
| dc.description | © 2017 Published by Elsevier Inc. | pt_PT |
| dc.description.abstract | Mitochondria have a pivotal role in the maintenance of cell homeostasis and survival. Mitochondria are involved in processes such as ATP production, reactive oxygen species production, apoptosis induction, calcium homeostasis and protein degradation. Thus, mechanisms that regulate the intrinsic quality of mitochondria have a crucial role in dictating overall cell fate. The importance of these well-regulated mechanisms is highlighted in disease scenarios such as neurodegeneration, cancer and neuromuscular atrophy. How mitochondria senses and regulates their intrinsic quality control, and consequently cell survival, is still not fully understood. In this review, we discuss the pathways that are at present considered as state-of-the-art for mitochondria quality control regulation, and highlight a mitochondrial protein-PINK1-that has revealed to act as a mitochondrial gatekeeper able to sense the presence of healthy or damaged mitochondria. | pt_PT |
| dc.description.sponsorship | This work was supported by the Fundação para a Ciência e Tecnologia - FCT, European Molecular Biology Organization - EMBOIG#3309, and European Research Council Starting Grant - ERCStG#679168. EPL is holder of an FCT PhD fellowship (PD/BD/128289/2017). VAM is an iFCT researcher. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Biochem Biophys Res Commun. 2018 May 27;500(1):45-50 | pt_PT |
| dc.identifier.doi | 10.1016/j.bbrc.2017.06.096 | pt_PT |
| dc.identifier.eissn | 1090-2104 | |
| dc.identifier.issn | 0006-291X | |
| dc.identifier.uri | http://hdl.handle.net/10451/47094 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.relation | EMBOIG#3309 | pt_PT |
| dc.relation | The role of PINK1 in Mitochondrial Quality control and Neurodegenerative Diseases. | |
| dc.relation | Quality Control and Maintenance of Synaptic Mitochondria | |
| dc.relation.publisherversion | https://www.sciencedirect.com/journal/biochemical-and-biophysical-research-communications | pt_PT |
| dc.subject | Mitochondria | pt_PT |
| dc.subject | Mitophagy | pt_PT |
| dc.subject | PINK1 | pt_PT |
| dc.subject | Quality control | pt_PT |
| dc.title | Mitochondrial quality control pathways: PINK1 acts as a gatekeeper | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | The role of PINK1 in Mitochondrial Quality control and Neurodegenerative Diseases. | |
| oaire.awardTitle | Quality Control and Maintenance of Synaptic Mitochondria | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F128289%2F2017/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/EC/H2020/679168/EU | |
| oaire.citation.endPage | 50 | pt_PT |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | 45 | pt_PT |
| oaire.citation.title | Biochemical and Biophysical Research Communications | pt_PT |
| oaire.citation.volume | 500 | pt_PT |
| oaire.fundingStream | OE | |
| oaire.fundingStream | H2020 | |
| person.familyName | Leites | |
| person.familyName | Morais | |
| person.givenName | Elvira | |
| person.givenName | Vanessa | |
| person.identifier.ciencia-id | 3C18-1A78-9B45 | |
| person.identifier.orcid | 0000-0002-7225-7636 | |
| person.identifier.orcid | 0000-0002-0830-0548 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100008530 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | European Commission | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | article | pt_PT |
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