Repository logo
 
Publication

Improved Triamcinolone acetonide-eluting contact lenses based on cyclodextrins and high hydrostatic pressure assisted complexation

2024Journal article Open access
Simple item page
dc.contributor.authorMarto-Costa, Carolina
dc.contributor.authorToffoletto, Nadia
dc.contributor.authorSalema-Oom, Madalena
dc.contributor.authorAntunes, Alexandra M. M.
dc.contributor.authorPinto, Carlos A.
dc.contributor.authorSaraiva, Jorge A.
dc.contributor.authorSilva-Herdade, Ana S.
dc.contributor.authorAlvarez-Lorenzo, Carmen
dc.contributor.authorSerro, Ana
dc.date.accessioned2024-03-12T14:57:37Z
dc.date.available2024-03-12T14:57:37Z
dc.date.issued2024
dc.description© 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).pt_PT
dc.description.abstractContact lenses (CLs) constitute an advantageous platform for the topical release of corticosteroids due to their prolonged contact with the eye. However, the lipophilic nature of corticosteroids hampers CLs' ability to release therapeutic amounts. Two approaches to improve loading and release of triamcinolone acetonide (TA) from poly(2-hydroxyethyl methacrylate)-based hydrogels were investigated: adding 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) to the monomers solution before polymerization (HEMA/i-CD) and an hydrogels' post-treatment with HP-β-CD (HEMA/p-CD). The effect of HP-β-CD and sterilization by high hydrostatic pressure (HHP) on the hydrogel properties (water content, oxygen and ion permeability, roughness, transmittance, and stiffness) was evaluated. The HEMA/i-CD hydrogels had stronger affinity for TA, sustaining its release for one day. HHP sterilization promoted the formation of cyclodextrin-TA complexes within the hydrogels, improving their drug-loading capacity »60 %. Cytotoxicity and irritability tests confirmed the safety of the therapeutic CLs. TA released from the hydrogels permeated through ocular tissues ex vivo and showed anti-inflammatory activity. Finally, a previously validated mathematical model was used to estimate the ability of the TA-loaded CLs to deliver therapeutic drug concentrations to the posterior part of the eye. Overall, HP-β-CD-containing CLs are promising candidates for the topical ocular application of TA as an alternative delivery system to intraocular injections.pt_PT
dc.description.sponsorshipWork supported by Fundação para a Ciência e a Tecnologia (FCT) through [doi: 10.54499/UIDB/00100/2020] and [doi: 10.54499/UIDP/00100/2020] (CQE), [doi: 10.54499/UIDB/04585/2020] (CiiEM) and [doi:10.54499/PTDC/CTM-CTM/2353/2021] (SOL project), University of Aveiro and FCT/MCT through [UIDB/50006/2020 and UIDP/50006/2020] (LAQV-REQUIMTE) co-funded by the FEDER within PT2020 Partnership Agreement, and MCIN/AEI/10.13039/501100011033 Spain [PID 2020-113881RB-I00], Xunta de Galicia [ED431C 2020/17], and FEDER. The authors acknowledge SICASAL - Indústria e Comércio de Carnes, S.A. for the kind supply of porcine fresh eyes and to Dr. Nuno Taveira from the University of Lisbon for providing THP-1 human monocytes cell line. ASHLAND kindly provided Cavasol® W7 HP PHARMA (HP-β-CD). The Graphical Abstract was created by using pictures from Servier Medical Art., by Servier, licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCarbohydr Polym. 2024 May 1:331:121880pt_PT
dc.identifier.doi10.1016/j.carbpol.2024.121880pt_PT
dc.identifier.eissn1879-1344
dc.identifier.issn0144-8617
dc.identifier.urihttp://hdl.handle.net/10451/63374
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationCentro de Química Estrutural
dc.relationCentro de Química Estrutural
dc.relationEgas Moniz Interdisciplinary Research Center
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/carbohydrate-polymerspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCyclodextrinpt_PT
dc.subjectDiabetic macularpt_PT
dc.subjectedemapt_PT
dc.subjectDrug-eluting contact lensespt_PT
dc.subjectHigh hydrostatic pressure sterilizationpt_PT
dc.subjectTriamcinolone acetonidept_PT
dc.titleImproved Triamcinolone acetonide-eluting contact lenses based on cyclodextrins and high hydrostatic pressure assisted complexationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentro de Química Estrutural
oaire.awardTitleCentro de Química Estrutural
oaire.awardTitleEgas Moniz Interdisciplinary Research Center
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00100%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00100%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04585%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos IC&DT em Todos os Domínios Científicos/PTDC%2FCTM-CTM%2F2353%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.citation.titleCarbohydrate Polymerspt_PT
oaire.citation.volume331pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso de Projetos IC&DT em Todos os Domínios Científicos
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMarto Costa
person.familyNameToffoletto
person.familyNameAntunes
person.familyNameSilva-Herdade
person.familyNameSerro
person.givenNameCarolina
person.givenNameNadia
person.givenNameAlexandra
person.givenNameAna S.
person.givenNameAna
person.identifier674240
person.identifier749915
person.identifier.ciencia-idAA1B-F8A2-C4C5
person.identifier.ciencia-id551F-9CBD-EECD
person.identifier.ciencia-idD11E-FC6A-6438
person.identifier.ciencia-id6517-B340-F362
person.identifier.ciencia-idC012-F8B6-A58E
person.identifier.orcid0000-0002-1039-7203
person.identifier.orcid0000-0002-2321-906X
person.identifier.orcid0000-0003-1827-7369
person.identifier.orcid0000-0002-3023-1315
person.identifier.orcid0000-0002-6179-9296
person.identifier.ridJOZ-3484-2023
person.identifier.ridB-7871-2009
person.identifier.ridB-2735-2019
person.identifier.ridH-7797-2012
person.identifier.scopus-author-id23977430200
person.identifier.scopus-author-id6603259828
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication11e54b3b-e51a-4547-af65-ce9822d49fe4
relation.isAuthorOfPublicationbae0ee3f-374d-4e08-b396-f586f6dfd6a3
relation.isAuthorOfPublicationcf1f4bc7-3ddc-44e1-8d20-8ce073c82d48
relation.isAuthorOfPublicationad32fa9b-85eb-4679-a4c9-9f6109423b88
relation.isAuthorOfPublicationa6ae3bec-c21e-48e1-b036-7b4ba1de0f0c
relation.isAuthorOfPublication.latestForDiscoverya6ae3bec-c21e-48e1-b036-7b4ba1de0f0c
relation.isProjectOfPublication6f563b11-7a3d-4ed6-9d77-235805ada8d4
relation.isProjectOfPublication4ca7dc25-c6e3-4605-9ba5-0323b60389ea
relation.isProjectOfPublication51f64c55-6721-41b9-a54e-6f32e352ca67
relation.isProjectOfPublicationc3bbf2e0-be25-4a2c-a3a8-3f1bb014d1a2
relation.isProjectOfPublicationbe39fa48-21c8-44d1-bb97-d740294ed742
relation.isProjectOfPublication90be4d6f-d2bf-42cf-89fd-77c13fad615b
relation.isProjectOfPublication.latestForDiscoveryc3bbf2e0-be25-4a2c-a3a8-3f1bb014d1a2

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Improved_triamcinolone.pdf
Size:
1.83 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

IMM - Artigos em Revistas Internacionais
FM-IB-Artigos em Revistas Internacionais