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Sex differences in functional connectivity between resting state brain networks in Autism Spectrum Disorder

2021Journal article Open access
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dc.contributor.authorTavares, Vânia
dc.contributor.authorFernandes, Luís Afonso
dc.contributor.authorAntunes, Marilia
dc.contributor.authorFerreira, Hugo
dc.contributor.authorPrata, Diana
dc.date.accessioned2021-09-24T17:41:23Z
dc.date.available2021-09-24T17:41:23Z
dc.date.issued2021
dc.description© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.pt_PT
dc.description.abstractFunctional brain connectivity (FBC) has previously been examined in autism spectrum disorder (ASD) between-resting-state networks (RSNs) using a highly sensitive and reproducible hypothesis-free approach. However, results have been inconsistent and sex differences have only recently been taken into consideration using this approach. We estimated main effects of diagnosis and sex and a diagnosis by sex interaction on between-RSNs FBC in 83 ASD (40 females/43 males) and 85 typically developing controls (TC; 43 females/42 males). We found increased connectivity between the default mode (DM) and (a) the executive control networks in ASD (vs. TC); (b) the cerebellum networks in males (vs. females); and (c) female-specific altered connectivity involving visual, language and basal ganglia (BG) networks in ASD-in suggestive compatibility with ASD cognitive and neuroscientific theories.pt_PT
dc.description.sponsorshipVT received support from Fundação Ciência e Tecnologia (FCT) PhD fellowship (PD/BD/114460/2016) and paid by FCT DSAIPA/DS/0065/2018 Grant. DP was supported by the European Commission Seventh Framework Programme Marie Curie Career Integration Grant FP7-PEOPLE-2013-CIG-631952, the 2016 Bial Foundation Psychophysiology Grant Ref. 292/16, and the IF/00787/2014, LISBOA-01-0145-FEDER-030907 and DSAIPA/DS/0065/2018 FCT Grants, and the iMM Lisboa Director’s Fund Breakthrough Idea Grant 2016; and is co-founder and shareholder of the neuroimaging research services company NeuroPsyAI, Ltd. MA was supported by FCT Grant UID/MAT/00006/2013.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Autism Dev Disord. 2021 Jul 16pt_PT
dc.identifier.doi10.1007/s10803-021-05191-6pt_PT
dc.identifier.eissn1573-3432
dc.identifier.issn0162-3257
dc.identifier.urihttp://hdl.handle.net/10451/49630
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relationFP7-PEOPLE-2013-CIG-631952pt_PT
dc.relationLISBOA-01-0145-FEDER-030907pt_PT
dc.relation.publisherversionhttps://www.springer.com/journal/10803pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAutism spectrum disorderpt_PT
dc.subjectFunctional connectivitypt_PT
dc.subjectFunctional magnetic resonance imagingpt_PT
dc.subjectIndependent component analysispt_PT
dc.subjectResting-state networkspt_PT
dc.titleSex differences in functional connectivity between resting state brain networks in Autism Spectrum Disorderpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/55318/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCTI/2067/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/154483/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMAT%2F00006%2F2013/PT
oaire.citation.titleJournal of Autism and Developmental Disorderspt_PT
oaire.fundingStreamOE
oaire.fundingStreamPOCTI
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
person.familyNameTavares
person.familyNamede Sousa Antunes
person.familyNamePinto Prata
person.givenNameVânia
person.givenNameMarilia Cristina
person.givenNameDiana Maria
person.identifierG-8864-2015
person.identifierYaC5f4AAAAAJ&hl
person.identifier.ciencia-id1A16-4A6A-A8F9
person.identifier.ciencia-id7B18-C8FC-904C
person.identifier.orcid0000-0002-7446-4444
person.identifier.orcid0000-0002-1257-2829
person.identifier.orcid0000-0002-4051-022X
person.identifier.scopus-author-id16300632900
person.identifier.scopus-author-id14632352500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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