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Cannabis-Based Products for the Treatment of Skin Inflammatory Diseases: A Timely Review

2022-02Artigo científico Acesso aberto
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dc.contributor.authorMartins, Ana
dc.contributor.authorGomes, Ana L.
dc.contributor.authorVilas Boas, Inês
dc.contributor.authorMarto, Joana
dc.contributor.authorRibeiro, Helena
dc.date.accessioned2023-08-16T18:45:33Z
dc.date.available2023-08-16T18:45:33Z
dc.date.issued2022-02
dc.date.updated2022-12-17T15:47:31Z
dc.description© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.description.abstractThe use of natural products in dermatology is increasingly being pursued due to sustainability and ecological issues, and as a possible way to improve the therapeutic outcome of chronic skin diseases, relieving the burden for both patients and healthcare systems. The legalization of cannabis by a growing number of countries has opened the way for researching the use of cannabinoids in therapeutic topical formulations. Cannabinoids are a diverse class of pharmacologically active compounds produced by Cannabis sativa (phytocannabinoids) and similar molecules (endocannabinoids, synthetic cannabinoids). Humans possess an endocannabinoid system involved in the regulation of several physiological processes, which includes naturally-produced endocannabinoids, and proteins involved in their transport, synthesis and degradation. The modulation of the endocannabinoid system is a promising therapeutic target for multiple diseases, including vascular, mental and neurodegenerative disorders. However, due to the complex nature of this system and its crosstalk with other biological systems, the development of novel target drugs is an ongoing challenging task. The discovery of a skin endocannabinoid system and its role in maintaining skin homeostasis, alongside the anti-inflammatory actions of cannabinoids, has raised interest in their use for the treatment of skin inflammatory diseases, which is the focus of this review. Oral treatments are only effective at high doses, having considerable adverse effects; thus, research into plant-based or synthetic cannabinoids that can be incorporated into high-quality, safe topical products for the treatment of inflammatory skin conditions is timely. Previous studies revealed that such products are usually well tolerated and showed promising results for example in the treatment of atopic dermatitis, psoriasis, and contact dermatitis. However, further controlled human clinical trials are needed to fully unravel the potential of these compounds, and the possible side effects associated with their topical use.pt_PT
dc.description.sponsorshipThis research was funded by FCT (Fundação para a Ciência e a Tecnologia) through iMed.ULisboa UID/DTP/04138/2020 and UIDB/04138/2020). Joana Marto is financed through FCT, I.P., under the Scientific Employment Stimulus—Institutional Call (CEECINST/00145/2018).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMartins AM, Gomes AL, Vilas Boas I, Marto J, Ribeiro HM. Cannabis-Based Products for the Treatment of Skin Inflammatory Diseases: A Timely Review. Pharmaceuticals [Internet]. 2022 Feb 9;15(2):210. Available from: http://dx.doi.org/10.3390/ph15020210pt_PT
dc.identifier.doi10.3390/ph15020210pt_PT
dc.identifier.otherhttps://www.mdpi.com/1424-8247/15/7/849
dc.identifier.slugcv-prod-2793037
dc.identifier.urihttp://hdl.handle.net/10451/58903
dc.identifier.urihttp://hdl.handle.net/10451/59298
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationUID/DTP/04138/2020pt_PT
dc.relationResearch Institute for Medicines
dc.relationNot Available
dc.relationNot Available
dc.relationNot Available
dc.relation.publisherversionhttps://www.mdpi.com/1424-8247/15/2/210pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCannabis sativapt_PT
dc.subjectCannabinoidspt_PT
dc.subjectCBDpt_PT
dc.subjectTHCpt_PT
dc.subjectDermatological inflammatory diseasespt_PT
dc.titleCannabis-Based Products for the Treatment of Skin Inflammatory Diseases: A Timely Reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00145%2F2018%2FCP1571%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00145%2F2018%2FCP1571%2FCT0002/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00145%2F2018%2FCP1571%2FCT0003/PT
oaire.citation.issue2pt_PT
oaire.citation.startPage210pt_PT
oaire.citation.titlePharmaceuticalspt_PT
oaire.citation.volume15pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC INST 2018
oaire.fundingStreamCEEC INST 2018
oaire.fundingStreamCEEC INST 2018
person.familyNameMartins
person.familyNameMarques Marto
person.familyNameRibeiro
person.givenNameAna
person.givenNameJoana
person.givenNameHelena
person.identifier1570599
person.identifier.ciencia-id891B-12E1-C2BF
person.identifier.ciencia-id161F-B79B-D660
person.identifier.orcid0000-0003-4822-3249
person.identifier.orcid0000-0001-5523-5622
person.identifier.orcid0000-0002-2429-7991
person.identifier.ridE-2944-2015
person.identifier.scopus-author-id35896704400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid891B-12E1-C2BF | Joana Marques Marto
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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FF - CiênciaVitae - Faculdade de Farmácia