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Osteomyelitis caused by Aspergillus terreus complex in a dog: a case report

2023-06-08Artigo científico Acesso aberto
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dc.contributor.authorAbreu, Raquel
dc.contributor.authorMartinho, António
dc.contributor.authorNoiva, Rute
dc.contributor.authorPissarra, Hugo
dc.contributor.authorCota, João
dc.contributor.authorCunha, Eva
dc.contributor.authorTavares, Luis
dc.contributor.authorOliveira, Manuela
dc.date.accessioned2024-06-29T18:47:30Z
dc.date.available2024-06-29T18:47:30Z
dc.date.issued2023-06-08
dc.descriptionResearch Areas: Veterinary Sciencespt_PT
dc.description.abstractBackground In dogs, the most frequently reported mycosis associated with Aspergillus spp. are respiratory infections. Systemic aspergillosis is uncommon, with reported cases been associated with several Aspergillus species. Aspergillus terreus species complex are ubiquitous organisms, unfrequently associated with local or systemic disease in animals and humans, and treatment of osteomyelitis caused by this species is usually unfavorable. Case presentation This case report describes the case of a 5-year-old dog, referred to the Veterinary Hospital of the Faculty of Veterinary Medicine of the University of Lisbon, Portugal, with a history of lameness of the right thoracic limb. Radiographs and CT scan revealed two diferent lesions on right humerus and radio, which were biopsied. The samples collected were submitted to cytological and histopathological evaluation and bacterial and mycological culture. Environmental samples, including of the surgery room and of the biopsy needle were also evaluated for the presence of fungi. Regarding biopsy samples, bacterial culture was negative, but mycological analysis originated a pure culture of a fungal species later identifed as Aspergillus terreus by Sanger sequencing. Results were compatible with histopathologic examination, which revealed periosteal reaction and invasion of hyphae elements. Also, mycological analysis of both environmental samples evaluated were negative. The virulence profle of the fungal isolate was phenotypically characterized using specifc media, allowing to reveal its ability to produce several enzymes involved in its pathogenicity, namely lipase, hemolysin and DNAse, corresponding to a Virulence Index (V. Index.) of 0.43. The patient was submitted to itraconazole therapy for 8 weeks. After 3 weeks, the patient showed signifcant clinical improvement, and after 6 weeks no radiographic signs were observed. Conclusions Antifungal therapy with itraconazole can contribute to the remission of canine infections promoted by Aspergillus terreus complex with a relevant V. Indexpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAbreu R, Martinho A, Noiva R, Pissarra H, Cota J, Cunha E, Tavares L, Oliveira M. 2023. Osteomyelitis caused by Aspergillus terreus complex in a dog: a case report. BMC Veterinary Research, 19(1). doi:10.1186/s12917-023-03628-xpt_PT
dc.identifier.doi10.1186/s12917-023-03628-xpt_PT
dc.identifier.eissn1746-6148
dc.identifier.urihttp://hdl.handle.net/10400.5/31197
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMCpt_PT
dc.relationLA/P/0059/2020AL4AnimalSpt_PT
dc.relationCentre for Interdisciplinary Research in Animal Health
dc.relation.publisherversionhttps://bmcvetres.biomedcentral.com/articles/10.1186/s12917-023-03628-xpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDogpt_PT
dc.subjectAspergillus terreus complexpt_PT
dc.subjectFungal osteomyelitispt_PT
dc.subjectItraconazolept_PT
dc.titleOsteomyelitis caused by Aspergillus terreus complex in a dog: a case reportpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Interdisciplinary Research in Animal Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00276%2F2020/PT
oaire.citation.conferencePlaceLondon, Englandpt_PT
oaire.citation.endPage8pt_PT
oaire.citation.issue76pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleBMC Veterinary Researchpt_PT
oaire.citation.volume19(1)pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAbreu
person.familyNameNoiva
person.familyNameMartins Pissarra
person.familyNameBettencourt Barcelos Cota
person.familyNameGonçalves da Cunha
person.familyNameMorgado Tavares
person.familyNameOliveira
person.givenNameRaquel
person.givenNameRute
person.givenNameHugo Abel Sampaio Monteiro
person.givenNameJoão
person.givenNameEva Sofia
person.givenNameLuis Manuel
person.givenNameManuela
person.identifier.ciencia-id881E-0612-50D8
person.identifier.ciencia-idF612-AEDD-0EF9
person.identifier.ciencia-idE51C-30A8-DEC8
person.identifier.ciencia-id9811-7B6B-E2B9
person.identifier.ciencia-id9011-18C6-482D
person.identifier.ciencia-idBE1E-2B3B-92D2
person.identifier.orcid0000-0001-8063-174X
person.identifier.orcid0000-0001-8227-4950
person.identifier.orcid0000-0003-3897-9376
person.identifier.orcid0000-0002-9756-7913
person.identifier.orcid0000-0002-5641-4400
person.identifier.orcid0000-0001-8671-6285
person.identifier.orcid0000-0002-3910-1525
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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