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Innovative, Sugar-Free Oral Hydrogel as a Co-administrative Vehicle for Pediatrics: a Strategy to Enhance Patient Compliance

2022-05Artigo científico Acesso restrito
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dc.contributor.authorPereira, Margarida
dc.contributor.authorCosme Silva, Filipa
dc.contributor.authorSimões, Sandra
dc.contributor.authorRibeiro, Helena
dc.contributor.authorAlmeida, António José
dc.contributor.authorMarto, Joana
dc.date.accessioned2023-08-21T14:01:48Z
dc.date.available2023-08-21T14:01:48Z
dc.date.issued2022-05
dc.date.updated2022-12-17T15:36:19Z
dc.description.abstractPalatability and swallowability in the pediatric population are perceived as true challenges in the oral administration of medication. Pediatric patients have high sensitivity to taste and reduced ability to take solid dosage forms, which can often lead to a poor therapeutic compliance. It is crucial to find new strategies to simplify the oral administration of drugs to children. The present paper reports the development of a new hydrogel vehicle adapted to the pediatric population. Several polymers with similar properties were selected and adjustments were made to obtain the desired characteristics of the final product. The developed formulations were studied for organoleptic properties, rheology, mucoadhesion properties, preservative efficacy, and stability. Physical and chemical compatibilities between the vehicle and several drugs/medicines, at the time of administration, were also studied. Six final formulations with different polymers, odor, and color were chosen, and no known interactions with medications were observed. The proposed new oral vehicles are the first sugar-free vehicle hydrogels designed to make the intake of oral solid forms a more pleasant and safer experience for pediatric patients.pt_PT
dc.description.sponsorshipThis research was funded by FCT (Fundação para a Ciência e a Tecnologia) through iMed.ULisboa UID/DTP/04138/2020 and UIDB/04138/2020). Joana Marto is financed through FCT, I.P., under the Scientific Employment Stimulus—Institutional Call (CEECINST/00145/2018).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPereira M, Silva FC, Simões S, Ribeiro HM, Almeida AJ, Marto J. Innovative, sugar-free oral hydrogel as a co-administrative vehicle for pediatrics: a strategy to enhance patient compliance. AAPS PharmSciTech [Internet]. 5 de abril de 2022;23(4):107. Disponível em: https://doi.org/10.1208/s12249-022-02265-1pt_PT
dc.identifier.doi10.1208/s12249-022-02265-1pt_PT
dc.identifier.slugcv-prod-3098155
dc.identifier.urihttp://hdl.handle.net/10451/58940
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationUID/DTP/04138/2020pt_PT
dc.relationResearch Institute for Medicines
dc.relationNot Available
dc.relationNot Available
dc.relationNot Available
dc.relation.publisherversionhttps://link.springer.com/article/10.1208/s12249-022-02265-1pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPediatric vehiclept_PT
dc.subjectHydrogelpt_PT
dc.subjectSwallowabilitypt_PT
dc.subjectPalatabilitypt_PT
dc.subjectOral administrationpt_PT
dc.titleInnovative, Sugar-Free Oral Hydrogel as a Co-administrative Vehicle for Pediatrics: a Strategy to Enhance Patient Compliancept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDB/04138/2020
oaire.awardNumberCEECINST/00145/2018/CP1571/CT0001
oaire.awardNumberCEECINST/00145/2018/CP1571/CT0002
oaire.awardNumberCEECINST/00145/2018/CP1571/CT0003
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00145%2F2018%2FCP1571%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00145%2F2018%2FCP1571%2FCT0002/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00145%2F2018%2FCP1571%2FCT0003/PT
oaire.citation.issue4pt_PT
oaire.citation.startPage107pt_PT
oaire.citation.titleAAPS PharmSciTechpt_PT
oaire.citation.volume23pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC INST 2018
oaire.fundingStreamCEEC INST 2018
oaire.fundingStreamCEEC INST 2018
person.familyNameCosme Silva
person.familyNameSimões
person.familyNameRibeiro
person.familyNameLeitão das Neves Almeida
person.familyNameMarques Marto
person.givenNameFilipa
person.givenNameSandra
person.givenNameHelena
person.givenNameAntónio José
person.givenNameJoana
person.identifierC-2614-2014
person.identifier1570599
person.identifierI-6590-2012
person.identifier.ciencia-idDB11-CCE8-1E9B
person.identifier.ciencia-id4011-196E-E4EA
person.identifier.ciencia-id161F-B79B-D660
person.identifier.ciencia-id8312-F853-C47A
person.identifier.ciencia-id891B-12E1-C2BF
person.identifier.orcid0000-0002-1711-5627
person.identifier.orcid0000-0002-5685-1790
person.identifier.orcid0000-0002-2429-7991
person.identifier.orcid0000-0002-7807-4726
person.identifier.orcid0000-0001-5523-5622
person.identifier.ridE-2944-2015
person.identifier.scopus-author-id8724939200
person.identifier.scopus-author-id35896704400
person.identifier.scopus-author-id57195052432
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid891B-12E1-C2BF | Joana Marques Marto
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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FF - CiênciaVitae - Faculdade de Farmácia