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The effects of prostaglandin E-2 treatment on the secretory function of mare corpus luteum depends on the site of application : an in vivo study

2022-02-15Artigo científico Acesso aberto
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dc.contributor.authorPiotrowska-Tomala, Katarzyna K.
dc.contributor.authorJonczyk, Agnieszka W.
dc.contributor.authorSzostek-Mioduchowska, Anna Z.
dc.contributor.authorZebrowska, Ewelina
dc.contributor.authorFerreira-Dias, Graça
dc.contributor.authorSkarzynski, Dariusz J.
dc.date.accessioned2022-04-27T22:01:08Z
dc.date.available2022-04-27T22:01:08Z
dc.date.issued2022-02-15
dc.descriptionResearch Areas: Veterinary Sciencespt_PT
dc.description.abstractWe examined the effect of prostaglandin (PG) E2 on the secretory function of equine corpus luteum (CL), according to the application site: intra-CL injection vs. an intrauterine (intra-U) administration. Moreover, the effect of intra-CL injection vs. intra-U administration of both luteotropic factors: PGE2 and human chorionic gonadotropin (hCG) as a positive control, on CL function was additionally compared. Mares were assigned to the groups (n = 6 per group): (1) an intra-CL saline injection (control); (2) an intra-CL injection of PGE2 (5 mg/ml); (3) an intra-CL injection of hCG (1,500 IU/ml); (4) an intra-U saline administration (control); (5) an intra-U administration of PGE2 (5 mg/5 ml); (6) an intra-U administration of hCG (1,500 IU/5 ml). Progesterone (P4) and PGE2 concentrations were measured in blood plasma samples collected at −2, −1, and 0 (pre-treatment), and at 1, 2, 3, 4, 6, 8, 10, 12, and 24 h after treatments. Moreover, effects of different doses of PGE2 application on the concentration of total PGF2α (PGF2α and its main metabolite 13,14-dihydro-15-keto-prostaglandin F2α– PGFM) was determined. The time point of PGE2, hCG, or saline administration was defined as hour “0” of the experiment. An intra-CL injection of PGE2 increased P4 and PGE2 concentrations between 3 and 4 h or at 3 and 12 h, respectively (p < 0.05). While intra-U administration of PGE2 elevated P4 concentrations between 8 and 24 h, PGE2 was upregulated at 1 h and between 3 and 4 h (p < 0.05). An intra-CL injection of hCG increased P4 concentrations at 1, 6, and 12 h (p < 0.05), while its intra-U administration enhanced P4 and PGE2 concentrations between 1 and 12 h or at 3 h and between 6 and 10 h, respectively (p < 0.05). An application of PGE2, dependently on the dose, supports equine CL function, regardless of the application site, consequently leading to differences in both P4 and PGE2 concentrations in blood plasmapt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPiotrowska-Tomala KK, Jonczyk AW, Szostek-Mioduchowska AZ, Zebrowska E, Ferreira-Dias G, Skarzynski DJ. 2022. The effects of prostaglandin E-2 treatment on the secretory function of mare corpus luteum depends on the site of application : an in vivo study. Frontiers Veterinary Science, 8:753796. DOI: 10.3389/fvets.2021.753796pt_PT
dc.identifier.doi10.3389/fvets.2021.753796pt_PT
dc.identifier.eissn2297-1769
dc.identifier.urihttp://hdl.handle.net/10400.5/24182
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relation2011/02/A/NZ5/00338pt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fvets.2021.753796/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectProstaglandin E2pt_PT
dc.subjectHuman chorion gonadotropin, corpus luteum, progesterone, marept_PT
dc.subjectCorpus luteumpt_PT
dc.subjectProgesteronept_PT
dc.subjectMarept_PT
dc.titleThe effects of prostaglandin E-2 treatment on the secretory function of mare corpus luteum depends on the site of application : an in vivo studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceLausanne, Switzerlandpt_PT
oaire.citation.titleFrontiers in Veterinary Sciencept_PT
oaire.citation.volume8:753796pt_PT
person.familyNameLeitão Ferreira-Dias
person.givenNameGraça Maria
person.identifier.ciencia-idF51C-7F45-C720
person.identifier.orcid0000-0003-0622-6513
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0fb8ec33-7ee1-482b-bdcb-eff773226f90
relation.isAuthorOfPublication.latestForDiscovery0fb8ec33-7ee1-482b-bdcb-eff773226f90

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