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Metadherin expression and lung relapse in patients with colorectal carcinoma

2014Journal article Restricted access
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dc.contributor.authorCasimiro, Sandra
dc.contributor.authorFernandes, Afonso
dc.contributor.authorOliveira, Antonio
dc.contributor.authorFranco, Marco
dc.contributor.authorPires, Ricardo
dc.contributor.authorPeres, Mafalda
dc.contributor.authorMatias, Margarida
dc.contributor.authorTato-Costa, Joana
dc.contributor.authorCarvalho Guerra, Nuno
dc.contributor.authorRamos, Madalena
dc.contributor.authorCruz, Jorge
dc.contributor.authorCosta, Luis
dc.date.accessioned2022-09-28T14:58:41Z
dc.date.available2022-09-28T14:58:41Z
dc.date.issued2014
dc.description© Springer Science+Business Media Dordrecht 2014pt_PT
dc.description.abstractColorectal cancer (CRC) is the third most common malignant disease in men and the second in women worldwide. CRC relapse occurs mostly in liver and lungs, decreasing the 5-year survival to 6 %. Metadherin (MTDH) is overexpressed in several types of cancer, has been implicated in proliferation, invasion, metastasis, angiogenesis, and chemoresistance, and is a factor of poor prognosis in CRC. In this work we addressed the prognostic significance of MTDH expression in CRC progression to the lungs. We found that MTDH gene was more frequently amplified (copy number >1.8) in patients with CRC and relapse to the lung, when compared to patients without lung metastases (17.4 vs 100 %; p < 0.001). We observed a correlation between MTDH gene copy number and MTDH expression by IHC (p = 0.0001). Next we also analyzed MTDH expression by IHC in samples from 85 patients diagnosed with CRC, stage II or III, M0, with at least 3 years of follow-up. Kaplan-Meier survival analysis showed that lung relapse-free survival (HR 5.29, 95 % CI 1.90-14.77, p = 0.0004), liver relapse-free survival (HR 8.59, 95 % CI 0.99-74.18, p = 0.003), relapse-free survival (HR 4.85, 95 % CI 1.88-12.45, p = 0.0003) and overall survival (HR 3.75, 95 % CI 1.15-12.18, p = 0.018) were significantly lower in the group with high MTDH expression. Multivariate analysis showed that high MTDH expression was an independent factor for all outcomes. This study demonstrates that high MTDH expression is a biomarker of relapse in CRC, including lung-specific relapse. Determination of MTDH expression in primary CRC may be useful in the earlier detection of lung metastases in patients with high expression and increased risk.pt_PT
dc.description.sponsorshipThis project was supported by a Grant from Fundação para a Ciência e Tecnologia (PIC/IC/82821/2007).S. Casimiro was supported by a Post-Doctoral Grant (SFRH/BPD/34801/2007) and J. Tato-Costa by a PhD Grant (SFRH/BD/45219/2008) from Fundação para a Ciência e Tecnologia.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationClin Exp Metastasis. 2014 Aug;31(6):689-696pt_PT
dc.identifier.doi10.1007/s10585-014-9659-0pt_PT
dc.identifier.eissn1573-7276
dc.identifier.issn0262-0898
dc.identifier.urihttp://hdl.handle.net/10451/54623
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relationMECHANISMS OF INVASION AND PROGRESSION OF CANCER IN BONE: ROLE OF MATRIX METALLOPROTEASES
dc.relationSTROMAL-EPITHELIAL INTERACTIONS IN RECTAL CANCER:ROLE OF CHEMORADIOTHERAPY - INDUCED SENESCENCE IN CLINICAL OUTCOME
dc.relation.publisherversionhttps://www.springer.com/journal/10585pt_PT
dc.subjectMetadherinpt_PT
dc.subjectLung metastasispt_PT
dc.subjectColorectal cancerpt_PT
dc.subjectPrognostic factorpt_PT
dc.subjectLung-relapse free survivalpt_PT
dc.titleMetadherin expression and lung relapse in patients with colorectal carcinomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMECHANISMS OF INVASION AND PROGRESSION OF CANCER IN BONE: ROLE OF MATRIX METALLOPROTEASES
oaire.awardTitleSTROMAL-EPITHELIAL INTERACTIONS IN RECTAL CANCER:ROLE OF CHEMORADIOTHERAPY - INDUCED SENESCENCE IN CLINICAL OUTCOME
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5646-ICCMS/PIC%2FIC%2F82821%2F2007/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/PIDDAC/SFRH%2FBPD%2F34801%2F2007/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F45219%2F2008/PT
oaire.citation.endPage696pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage689pt_PT
oaire.citation.titleClinical & Experimental Metastasispt_PT
oaire.citation.volume31pt_PT
oaire.fundingStream5646-ICCMS
oaire.fundingStreamPIDDAC
person.familyNameCara de Anjo Casimiro
person.familyNameOliveira
person.familyNameCarvalho Guerra
person.familyNameCruz
person.familyNameCosta
person.givenNameSandra Cristina
person.givenNameAntonio
person.givenNameNuno
person.givenNameJorge
person.givenNameLuis
person.identifier.ciencia-id0F12-5181-0B22
person.identifier.ciencia-id2A15-B31C-0FFF
person.identifier.ciencia-id041E-4ADE-FB64
person.identifier.orcid0000-0002-6917-4477
person.identifier.orcid0000-0001-9103-6532
person.identifier.orcid0000-0003-3145-7399
person.identifier.orcid0000-0001-5361-0927
person.identifier.orcid0000-0002-4782-7318
person.identifier.scopus-author-id14043403400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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