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Synovial tissue research : a state-of-the-art review

2017-09-22Artigo científico Acesso restrito
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dc.contributor.authorOrr, Carl
dc.contributor.authorVieira de Sousa, Elsa Cristina
dc.contributor.authorBoyle, David L.
dc.contributor.authorBuch, Maya H.
dc.contributor.authorBuckley, Christopher D.
dc.contributor.authorCañete, Juan D.
dc.contributor.authorCatrina, Anca I.
dc.contributor.authorChoy, Ernest H. S.
dc.contributor.authorEmery, Paul
dc.contributor.authorFearon, Ursula
dc.contributor.authorFiler, Andrew
dc.contributor.authorGerlag, Danielle
dc.contributor.authorHumby, Frances
dc.contributor.authorIsaacs, John D.
dc.contributor.authorJust, Søren A.
dc.contributor.authorLauwerys, Bernard R.
dc.contributor.authorLe Goff, Benoit
dc.contributor.authorManzo, Antonio
dc.contributor.authorMcGarry, Trudy
dc.contributor.authorMcInnes, Iain B.
dc.contributor.authorNajm, Aurélie
dc.contributor.authorPitzalis, Constantino
dc.contributor.authorPratt, Arthur
dc.contributor.authorSmith, Malcolm
dc.contributor.authorTak, Paul P.
dc.contributor.authorThurlings, Rogier
dc.contributor.authorFonseca, João Eurico
dc.contributor.authorVeale, Douglas J.
dc.date.accessioned2021-03-10T12:41:04Z
dc.date.available2021-03-10T12:41:04Z
dc.date.issued2017-09-22
dc.descriptionCopyright © 2017, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.pt_PT
dc.description.abstractThe synovium is the major target tissue of inflammatory arthritides such as rheumatoid arthritis. The study of synovial tissue has advanced considerably throughout the past few decades from arthroplasty and blind needle biopsy to the use of arthroscopic and ultrasonographic technologies that enable easier visualization and improve the reliability of synovial biopsies. Rapid progress has been made in using synovial tissue to study disease pathogenesis, to stratify patients, to discover biomarkers and novel targets, and to validate therapies, and this progress has been facilitated by increasingly diverse and sophisticated analytical and technological approaches. In this Review, we describe these approaches, and summarize how their use in synovial tissue research has improved our understanding of rheumatoid arthritis and identified candidate biomarkers that could be used in disease diagnosis and stratification, as well as in predicting disease course and treatment response.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNat Rev Rheumatol. 2017 Dec 19;14 (1):60.pt_PT
dc.identifier.doi10.1038/nrrheum.2017.161pt_PT
dc.identifier.eissn1759-4804
dc.identifier.issn1759-4790
dc.identifier.urihttp://hdl.handle.net/10451/46770
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.nature.com/nrrheum/pt_PT
dc.titleSynovial tissue research : a state-of-the-art reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue10pt_PT
oaire.citation.titleNature Reviews Rheumatologypt_PT
oaire.citation.volume13pt_PT
person.familyNameVieira de Sousa
person.familyNameFonseca
person.givenNameElsa Cristina
person.givenNameJoão
person.identifier.ciencia-id1519-509A-8B89
person.identifier.ciencia-idF310-B85D-57C7
person.identifier.orcid0000-0002-7170-8802
person.identifier.orcid0000-0003-1432-3671
person.identifier.scopus-author-id7101983519
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8b9873ad-2667-48e6-aece-a73dec6a8296
relation.isAuthorOfPublication1772dc12-7c55-4c76-ae2d-c23270172480
relation.isAuthorOfPublication.latestForDiscovery1772dc12-7c55-4c76-ae2d-c23270172480

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