Publication
Gag-specific CD4+ T-cell frequency is inversely correlated with proviral load and directly correlated with immune activation in infection with human immunodeficiency virus type 2 (HIV-2) but not HIV-1
| dc.contributor.author | Foxall, R. B. | |
| dc.contributor.author | Cortesão, C. S. | |
| dc.contributor.author | Albuquerque, A. S. | |
| dc.contributor.author | Soares, R. S. | |
| dc.contributor.author | Victorino, R. M. | |
| dc.contributor.author | Sousa, A. E. | |
| dc.date.accessioned | 2015-02-03T16:13:25Z | |
| dc.date.available | 2015-02-03T16:13:25Z | |
| dc.date.issued | 2008 | |
| dc.description | Copyright © 2008, American Society for Microbiology. All Rights Reserved. | por |
| dc.description.abstract | Human immunodeficiency virus type 2 (HIV-2) infection, unlike HIV-1 infection, is normally characterized by low rates of CD4 depletion and low-to-undetectable viremia. We found that the frequency of Gag-specific CD4(+) T cells featured positive correlations with the expression of markers of CD4 activation and a negative correlation with peripheral blood mononuclear cell-associated proviral load in infection with HIV-2, in contrast with HIV-1. Moreover, HIV-2-infected individuals exhibited a greater ability to respond to HIV-1 Gag peptides (heterologous responses). Our data suggest a potential link between HIV-2-specific CD4 responses, immune activation, and viral control, which may in turn relate to the better prognosis associated with HIV-2 infection. | por |
| dc.description.sponsorship | This work was supported by grants from Fundação para a Ciência e a Tecnologia (FCT) and by Programa Operacional Ciência e Inovação 2010 (POCI 2010) to A.E.S. R.B.F., C.S.C., A.S.A., and R.S.S. received scholarships from FCT cofinanced by POCI 2010 and FSE. | por |
| dc.identifier.citation | Journal of Virology, Oct. 2008, Vol. 82, No. 19, p. 9795–9799 | por |
| dc.identifier.issn | 0022-538X | |
| dc.identifier.uri | http://dx.doi.org/10.1128/JVI.01217-08 | |
| dc.identifier.uri | http://hdl.handle.net/10451/15875 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | American Society for Microbiology | por |
| dc.relation.publisherversion | The definitive version is available at http://jvi.asm.org/ | por |
| dc.title | Gag-specific CD4+ T-cell frequency is inversely correlated with proviral load and directly correlated with immune activation in infection with human immunodeficiency virus type 2 (HIV-2) but not HIV-1 | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | Journal of Virology | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |