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The role of PD-L1 expression in pituitary tumours: lessons from the current literature

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dc.contributor.authorLopes-Pinto, Mariana
dc.contributor.authorLacerda-Nobre, Ema
dc.contributor.authorSilva, Ana Luísa
dc.contributor.authorTortosa, Francisco
dc.contributor.authorMarques, Pedro
dc.date.accessioned2024-06-19T11:40:29Z
dc.date.available2024-06-19T11:40:29Z
dc.date.issued2024
dc.description© 2024 S. Karger AG, Baselpt_PT
dc.description.abstractBackground: Programmed cell death-1 (PD-1) and PD ligand-1 (PD-L1) expression predict the biological behaviour, aggressiveness, and response to immune checkpoint inhibitors in different cancers. We reviewed the published data on PD-L1 expression in pituitary tumours from the perspective of its biological role and prognostic usefulness. Summary: A literature review focused on PD-L1 expression in pituitary tumours was performed. Six immunohistochemistry-based studies which assessed PD-L1 positivity in pituitary tumours were included, encompassing 704 patients. The cohort consisted of 384 (54.5%) nonfunctioning tumours and 320 (43.5%) functioning pituitary tumours. PD-L1 expression was positive in 248 cases (35.2%). PD-L1 positivity rate was higher in functioning than in nonfunctioning tumours (46.3% vs. 26.0%; p < 0.001) but also higher in growth hormone-secreting tumours (56.7%) and prolactinomas (53.6%) than in thyrotroph (33.3%) or corticotroph tumours (20.6%). While proliferative pituitary tumours showed higher rate of PD-L1 positivity than non-proliferative tumours (p < 0.001), no association with invasion or recurrence was found. Key messages: PD-L1 is expressed in a substantial number of pituitary tumours, predominantly in the functioning ones. PD-L1 positivity rates were significantly higher in proliferative pituitary tumours in comparison to non-proliferative tumours, but no differences were found concerning invasive or recurrent pituitary tumours. More studies following homogeneous and standardised methodologies are needed to fully elucidate the role and usefulness of PD-L1 expression in pituitary tumours.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNeuroendocrinology. 2024 May 16:1-12pt_PT
dc.identifier.doi10.1159/000539345pt_PT
dc.identifier.eissn1423-0194
dc.identifier.issn0028-3835
dc.identifier.urihttp://hdl.handle.net/10451/65074
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherKargerpt_PT
dc.relation.publisherversionhttps://karger.com/nenpt_PT
dc.subjectImmune checkpoint inhibitorspt_PT
dc.subjectImmunotherapypt_PT
dc.subjectNivolumabpt_PT
dc.subjectPembrolizumabpt_PT
dc.subjectPituitary adenomapt_PT
dc.subjectPituitary tumourpt_PT
dc.subjectProgrammed cell death ligand 1pt_PT
dc.subjectTumour microenvironmentpt_PT
dc.titleThe role of PD-L1 expression in pituitary tumours: lessons from the current literaturept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleNeuroendocrinologypt_PT
person.familyNameLopes-Pinto
person.familyNameLacerda Nobre Machado Caetano
person.familyNameSilva
person.givenNameMariana
person.givenNameEma Nobre
person.givenNameAna Luísa
person.identifier.ciencia-idD215-714A-CA06
person.identifier.orcid0000-0001-6751-6616
person.identifier.orcid0009-0005-9490-8427
person.identifier.orcid0000-0002-4839-8279
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication6bd90c35-3c21-433c-ae20-b6bcffd85481
relation.isAuthorOfPublication78b4c776-06d2-4843-8c6e-74ed4cf75df6
relation.isAuthorOfPublication093aa1a4-a2f3-469f-a4ce-c71cde6560ed
relation.isAuthorOfPublication.latestForDiscovery6bd90c35-3c21-433c-ae20-b6bcffd85481

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