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Characteristics and management of patients with cancer and atrial fibrillation

2024Artigo científico Acesso aberto
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dc.contributor.authorGulizia, Michele Massimo
dc.contributor.authorTurazza, Fabio Maria
dc.contributor.authorAmeri, Pietro
dc.contributor.authorAlings, Marco
dc.contributor.authorCollins, Ronan
dc.contributor.authorDe Luca, Leonardo
dc.contributor.authorDi Nisio, Marcello
dc.contributor.authorLucci, Donata
dc.contributor.authorGabrielli, Domenico
dc.contributor.authorJanssens, Stefan
dc.contributor.authorParrini, Iris
dc.contributor.authorPinto, Fausto J.
dc.contributor.authorZamorano, Jose
dc.contributor.authorColivicchi, Furio
dc.date.accessioned2024-07-25T10:45:11Z
dc.date.available2024-07-25T10:45:11Z
dc.date.issued2024
dc.description© 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND License (http://creativecommons.o r g/licences/by-nc-nd/4.0/pt_PT
dc.description.abstractPurpose: This study aimed to evaluate the cytotoxic effects of different topical hyaluronic acid-based gels on human gingival fibroblasts and oral bacteria. Methods: Four different hyaluronate gels - Bexident® Aftas (BA), GUM® AftaClear (AfC), Gengigel®(G), Aloclair® Plus (AlC) and a chlorhexidine gel - Bexident®Gums(BG) were selected. Human gingival fibroblasts (HGF) were seeded in 48-well plates with different gel/culture medium concentrations (v/v%) and cell viability was evaluated at 1 and 3 days of culture. Cell morphology was assessed, and alterations graded according to ISO 10993-5:2009(E). Streptococcus oralis CECT 907T colony was, seed on 48-well plate or spread onto the blood agar plates and exposed to the different gel's concentration. The optical density (OD) was assessed, and the diameter of the inhibition zone was measured (mm). Results: BA and G elicited reduced HGF cytotoxicity, followed by AfC. AlC and BG were cytotoxic at concentrations up to 3% for all exposure times. PCM images of HGF showed moderate-to-severe alterations for AlC and BG and slight to mild changes, for BA, AfC and G. The highest antibacterial activity against S.oralis was observed on AlC and AfC, and no antibacterial activity was observed for BA and G. Inhibitory effect in sessile colonies was only observed in AlC and BG. Conclusions: AlC demonstrated superior antibacterial activities against S.oralis but a higher cytotoxic potential in HGF. BA and G presented the lowest cytotoxicity with little to no antibacterial effect. AfC demonstrated bacteriostatic effects and low cytotoxicity on HGF.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJACC Adv. 2024 Jul, 3 (7_Part_1)pt_PT
dc.identifier.doi10.1016/j.jacadv.2024.100991pt_PT
dc.identifier.eissn2772-963X
dc.identifier.urihttp://hdl.handle.net/10451/65464
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/jacc-advancespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAntibacterial propertiespt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectHyaluronic acidpt_PT
dc.subjectOral lesionspt_PT
dc.subjectTopical gelspt_PT
dc.titleCharacteristics and management of patients with cancer and atrial fibrillationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue7pt_PT
oaire.citation.titleJACC: Advancespt_PT
oaire.citation.volume3pt_PT
person.familyNamePinto
person.givenNameFausto J.
person.identifier1308889
person.identifier.ciencia-idC311-AEDD-6DBB
person.identifier.orcid0000-0002-8034-4529
person.identifier.ridG-9363-2015
person.identifier.scopus-author-id7102740158
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication5f44176f-69f5-482c-83cd-ab94425a6ec3
relation.isAuthorOfPublication.latestForDiscovery5f44176f-69f5-482c-83cd-ab94425a6ec3

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