Publication
Increased frequency of CD25dim CD4+ T-cells in HIV-2 infection, a naturally occurring attenuated form of HIV-1
| dc.contributor.author | Foxall, R. B. | |
| dc.contributor.author | Soares, R. S. | |
| dc.contributor.author | Albuquerque, A. S. | |
| dc.contributor.author | Cortesão, A. C. | |
| dc.contributor.author | Victorino, R. M. | |
| dc.contributor.author | Sousa, A. E. | |
| dc.date.accessioned | 2015-02-03T16:41:06Z | |
| dc.date.available | 2015-02-03T16:41:06Z | |
| dc.date.issued | 2008 | |
| dc.description | © 2008 Elsevier Inc. All rights reserved. | por |
| dc.description.abstract | The ability to maintain the CD4-memory pool is currently considered one of the main determinants of AIDS progression. Like HIV-1, HIV-2 infection is characterized by progressive hyper-immune activation, yet it is associated with slower rates of CD4-loss and reduced viremia irrespective of disease stage. In contrast to HIV-1, we observed an increased proportion of CD4(+) T-cells expressing CD25 in HIV-2 infected individuals, independent of the degree of CD4-depletion and levels of immune activation. This was due to CD4(+) T-cells expressing an intermediate intensity of CD25, characterized by an increased ability to produce IL-2 and a lack of other regulatory markers. This expansion, unique to HIV-2 seropositive individuals, may relate to an improved ability to replenish their CD4-memory pool, and thus to the better prognosis that characterizes HIV-2 infection. Identification of the underlying mechanisms regulating this population in HIV-1 and HIV-2 infections may provide a rational for novel therapeutic strategies. | eng |
| dc.description.sponsorship | This work was supported by grants from “Fundação para a Ciência e a Tecnologia” (FCT) and by “Programa Operacional Ciência e Inovação 2010” (POCI2010) to AES. RBF, RSS, ASA, and CSC received scholarships from FCT. | por |
| dc.identifier.citation | Clinical Immunology (2008) 127, 158–167 | por |
| dc.identifier.issn | 1521-6616 | |
| dc.identifier.uri | http://dx.doi.org/10.1016/j.clim.2008.01.008 | |
| dc.identifier.uri | http://hdl.handle.net/10451/15878 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Elsevier | por |
| dc.relation.publisherversion | The definitive version is available at http://www.sciencedirect.com/ | por |
| dc.subject | HIV/AIDS | por |
| dc.subject | HIV-2 | por |
| dc.subject | CD25 | por |
| dc.subject | T-cell subsets | por |
| dc.subject | Immune activation | por |
| dc.title | Increased frequency of CD25dim CD4+ T-cells in HIV-2 infection, a naturally occurring attenuated form of HIV-1 | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | Clinical Immunology | por |
| rcaap.rights | closedAccess | por |
| rcaap.type | article | por |