Publication
Effect of abietane diterpenes from Plectranthus grandidentatus on the growth of human cancer cell lines
| dc.contributor.author | Marques, CG | |
| dc.contributor.author | Pedro, M | |
| dc.contributor.author | Simoes, MFA | |
| dc.contributor.author | Nascimento, MSJ | |
| dc.contributor.author | Pinto, MMM | |
| dc.contributor.author | Rodriguez, B | |
| dc.date.accessioned | 2015-12-30T10:18:02Z | |
| dc.date.available | 2015-12-30T10:18:02Z | |
| dc.date.issued | 2002 | |
| dc.description.abstract | Five known abietane diterpenes, fatty acid esters of 7alpha-acyloxy-6beta-hydroxyroyleanone (1), grandidone A (2), 7alpha-acetoxy-6beta-hydroxyroyleanone (3), 6beta,7alpha-dihydroxyroyleanone (4), and coleon U (5), isolated from Plectranthus grandidentatus Gurke, were evaluated for their in vitro anti proliferative activity against five human cancer cell lines MCF-7, NCI-H460, SF-268, TK-10, and UACC-62. Coleon U (5) exhibited the strongest effect among all the assayed compounds. The abietane 3 revealed also a strong inhibitory effect while diterpenes 2 and 4 inhibited only slightly the growth of all cancer cell lines. | |
| dc.format | application/pdf | |
| dc.identifier.citation | PLANTA MEDICA. - Vol. 68, n. 9 (SEP 2002), p. 839-840 | |
| dc.identifier.issn | 0032-0943 | |
| dc.identifier.uri | http://hdl.handle.net/10451/21372 | |
| dc.language.iso | eng | |
| dc.publisher | GEORG THIEME VERLAG KG | |
| dc.subject | Plant Sciences | |
| dc.subject | Chemistry, Medicinal | |
| dc.subject | Pharmacology & Pharmacy | |
| dc.title | Effect of abietane diterpenes from Plectranthus grandidentatus on the growth of human cancer cell lines | |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 840 | por |
| oaire.citation.startPage | 839 | por |
| oaire.citation.title | PLANTA MEDICA | por |
| oaire.citation.volume | Vol. 68 | por |
| rcaap.rights | restrictedAccess | |
| rcaap.type | article |