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Publicação
Hotspot activating PRKD1 somatic mutations in polymorphous low-grad adenocarcinomas of the salivary glands
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Orientador(es)
Resumo(s)
Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functional studies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA.
Descrição
© 2014 Nature America, Inc. All rights reserved.
Palavras-chave
Contexto Educativo
Citação
Nat Genet. 2014 Nov;46(11):1166-1169
Editora
Springer Nature