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A high-risk carbapenem-resistant Pseudomonas aeruginosa clone detected in red deer (Cervus elaphus) from Portugal

2022-03Journal article Open access
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dc.contributor.authorTorres, Rita Tinoco
dc.contributor.authorCunha, Mónica V.
dc.contributor.authorFerreira, Helena
dc.contributor.authorFonseca, Carlos
dc.contributor.authorPalmeira, Josman Dantas
dc.date.accessioned2022-03-22T11:24:32Z
dc.date.available2024-03-01T01:30:52Z
dc.date.issued2022-03
dc.description.abstractPseudomonas aeruginosa is a ubiquitous bacterium, successfully exploiting a variety of environmental niches due to its remarkable metabolic versatility. The World Health Organization classifies P. aeruginosa as a “priority pathogen” due to its a great ability to overcome the action of antimicrobials, including carbapenems. Hitherto, most studies have focused on clinical settings from humans, but much less on animal and environmental settings, particularly on wildlife. In this work, we report the isolation of a carbapenem-resistant Pseudomonas aeruginosa strain recovered from the faeces of a red deer adult female sampled in a humanized area. This isolate was obtained during a nationwide survey on antimicrobial resistance in wildlife aimed to determine the occurrence of carbapenem-resistant bacteria among 181 widely distributed wild ungulates. This P. aeruginosa isolate was found to be a high-risk clone, belonging to the sequence type (ST) 274. The genomic analysis of P. aeruginosa isolate UP4, classified this isolate as belonging to serogroup O3, which was also found to harbour the genes blaPAO, blaPDC-24, blaOXA-486 (encoding resistance to beta-lactams), aph(3′)-IIb (aminoglycosides resistance), fosA (fosfomycin resistance) and catB7 (chloramphenicol resistance). Antimicrobial susceptibility screening, according to EUCAST, showed resistance to imipenem and intermediate resistance to meropenem and doripenem. To our knowledge, this is the first description of carbapenem-resistant P. aeruginosa in deer in Europe. Our results highlight the importance of wild ungulates either as victims of human activity or amplifiers of AMR, either way with potential impacts on animal, human and ecosystem health, since excretion of AMR bacteria might directly or indirectly contaminate other animals and the surrounding environment, perpetuating the spill-over and chain dissemination of AMR determinants.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationR.T. Torres, M.V. Cunha, H. Ferreira, et al., A high-risk carbapenem-resistant Pseudomonas aeruginosa clone detected in red deer (Cervus elaphus) from Portugal, Science of the Total Environment (2021), https://doi.org/10.1016/ j.scitotenv.2022.154699pt_PT
dc.identifier.doi10.1016/j.scitotenv.2022.154699pt_PT
dc.identifier.urihttp://hdl.handle.net/10451/51875
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPOCI-01-0145-FEDER-030310- funded by FEDERpt_PT
dc.relationFCT CESAM (UID/AMB/ 290 50017/2019)pt_PT
dc.relationAgriFood XXI (NORTE-01-0145-FEDER-000041)pt_PT
dc.relationFCT cE3c (UIDB/00329/2020)pt_PT
dc.relationFCT BioISI (UIDB/04046/2020)pt_PT
dc.relationFCT UCIBIO (UIDP/04378/2020 and UIDB/04378/2020)pt_PT
dc.titleA high-risk carbapenem-resistant Pseudomonas aeruginosa clone detected in red deer (Cervus elaphus) from Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage154699pt_PT
oaire.citation.titleScience of The Total Environmentpt_PT
person.familyNameCunha
person.givenNameMonica V.
person.identifier348477
person.identifier.ciencia-id5616-E715-2F31
person.identifier.orcid0000-0003-0401-0276
person.identifier.ridD-5544-2011
person.identifier.scopus-author-id7102711216
rcaap.embargofctO tipo de licença envolvido com a editora Elsevier para esta revista, não envolvendo pagamento (APC), apenas permite acesso em repositório público do formato 'aceite' (i.e não editado e paginado pela editora) após período de embargo de 24 meses após a data da sua publicação final.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa1b365bb-7421-4bf5-9cde-62b74c170e69
relation.isAuthorOfPublication.latestForDiscoverya1b365bb-7421-4bf5-9cde-62b74c170e69

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