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Cardiovascular and cerebrovascular risk markers in Parkinson’s disease: results from a case−control study

2021Journal article Restricted access
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dc.contributor.authorAlves, Mariana
dc.contributor.authorPita Lobo, Patrícia
dc.contributor.authorAzevedo Kauppila, Linda
dc.contributor.authorRebordão, Leonor
dc.contributor.authorCruz, M. Manuela
dc.contributor.authorSoares, Fátima
dc.contributor.authorCruz, João
dc.contributor.authorTornada, Ana
dc.contributor.authorCaldeira, Daniel
dc.contributor.authorReimão, Sofia
dc.contributor.authorOliveira, Victor
dc.contributor.authorFerro, José
dc.contributor.authorFerreira, Joaquim J
dc.date.accessioned2021-07-19T12:42:05Z
dc.date.available2021-07-19T12:42:05Z
dc.date.issued2021
dc.description© 2021 European Academy of Neurologypt_PT
dc.description.abstractBackground: The relationship between Parkinson's disease (PD) and cardiovascular and cerebrovascular disease is not yet well established. Recent data suggest an increased risk of myocardial infarction and stroke in PD patients. Therefore, we designed a study to assess surrogate markers of cardiovascular and cerebrovascular risk in PD. Methods: We conducted a case-control study comparing PD patients recruited from a Movement Disorders Unit with controls randomly invited from a primary healthcare center. All participants underwent a detailed clinical evaluation, including medical history, physical assessment, carotid ultrasound, blood and urine analysis, and 24-h ambulatory blood pressure monitoring. The primary outcome was the carotid intima-media thickness (CIMT). Results: We included 102 participants in each study arm. No significant difference was found in the CIMT among groups (MD: 0.01, 95% CI: -0.02, 0.04). Carotid plaques were more frequent in PD patients (OR: 1.90, 95% CI: 1.02, 3.55), although the lipid profile was more favorable in this group (LDL MD: -18.75; 95% CI: -10.69, -26.81). Nocturnal systolic blood pressure was significantly higher in PD patients (MD: 4.37, 95% CI: 0.27, 8.47) and more than half of the PD patients were non-dippers or reverse dippers (OR: 1.83, 95% CI: 1.04, 3.20). Conclusion: We did not find a difference in CIMT between PD and controls. A higher frequency of carotid plaques and abnormal dipper profile supports the hypothesis that PD patients are not protected from cardiovascular and cerebrovascular disease.pt_PT
dc.description.sponsorshipM.A. was awarded a scholarship from Fundação para a Ciência e Tecnologia (SFRH/BD/129700/2017). IMM - UID/BIM/50005/2019, project funded by Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through Fundos do Orçamento de Estadopt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Neurol. 2021 May 25pt_PT
dc.identifier.doi10.1111/ene.14938pt_PT
dc.identifier.eissn1468-1331
dc.identifier.issn1351-5101
dc.identifier.urihttp://hdl.handle.net/10451/48992
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley & Sons, Inc.pt_PT
dc.relationCardiovascular risk factors associated with Parkinson´s disease
dc.relationInstituto de Medicina Molecular
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/14681331pt_PT
dc.subjectParkinson's diseasept_PT
dc.subjectAtherosclerosispt_PT
dc.subjectCarotid arterypt_PT
dc.subjectIntima-media thicknesspt_PT
dc.subjectNocturnal blood pressurept_PT
dc.titleCardiovascular and cerebrovascular risk markers in Parkinson’s disease: results from a case−control studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCardiovascular risk factors associated with Parkinson´s disease
oaire.awardTitleInstituto de Medicina Molecular
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F129700%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIM%2F50005%2F2019/PT
oaire.citation.titleEuropean Journal of Neurologypt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAlves
person.familyNameAzevedo Kauppila
person.familyNameRebordão
person.familyNameCaldeira
person.familyNameReimão
person.familyNameOliveira
person.familyNameMorão Cabral Ferro
person.familyNameFerreira
person.givenNameMariana
person.givenNameLinda
person.givenNameLeonor
person.givenNameDaniel
person.givenNameSofia
person.givenNameVitor
person.givenNameJosé Manuel
person.givenNameJoaquim J
person.identifier1153684
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person.identifier.orcid0000-0002-1369-8423
person.identifier.orcid0000-0001-8463-5625
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person.identifier.orcid0000-0001-8483-8596
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person.identifier.orcid0000-0003-3950-5113
person.identifier.ridO-3034-2016
person.identifier.scopus-author-id56591535500
person.identifier.scopus-author-id36623384200
person.identifier.scopus-author-id52464128000
person.identifier.scopus-author-id7403252466
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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