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The impact of atrial voltage and conduction velocity phenotypes on atrial fibrillation recurrence

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dc.contributor.authorCunha, Pedro
dc.contributor.authorLaranjo, Sérgio
dc.contributor.authorMonteiro, Sofia
dc.contributor.authorPortugal, Guilherme
dc.contributor.authorGuerra, Cátia
dc.contributor.authorRocha, António Condeixa
dc.contributor.authorPereira, Mariana
dc.contributor.authorFerreira, Rui Cruz
dc.contributor.authorHeijman, Jordi
dc.contributor.authorOliveira, Mario
dc.date.accessioned2025-02-04T15:05:56Z
dc.date.available2025-02-04T15:05:56Z
dc.date.issued2024
dc.description© 2024 Silva Cunha, Laranjo, Monteiro, Portugal, Guerra, Rocha, Pereira, Ferreira, Heijman and Oliveira. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_PT
dc.description.abstractIntroduction: Low atrial voltage and slow conduction velocity (CV) have been associated with atrial fibrillation (AF); however, their interaction and relative importance as early disease markers remain incompletely understood. We aimed to elucidate the relationship between atrial voltage and CV using high-density electroanatomic (HDE) maps of patients with AF. Methods: HDE maps obtained during sinus rhythm in 52 patients with AF and five healthy controls were analysed. Atrial voltage and CV maps were generated, and their correlations were assessed. Subgroup analyses were performed based on clinically relevant factors such as AF type, CV, and voltage levels. Finally, cluster analysis was conducted to identify distinct phenotypes within the population, reflecting different patterns of conduction and voltage. Results: A moderate positive correlation was found between the mean atrial voltage and CV (r = 0.570). Subgroup analysis revealed differences in voltage (p = 0.0044) but not in global CV (p = 0.42), with no significant differences between AF types. Three distinct phenotypes emerged: normal voltage/normal CV, normal voltage/low CV, and low voltage/low CV, with distinct recurrence rates, suggesting different disease progression paths. Slower atrial CV was identified as a significant predictor of arrhythmia recurrence at 12 and 24 months after AF ablation, surpassing the predictive potential of atrial voltage. Conclusion: Atrial voltage and CV analyses revealed distinct phenotypes. Lower atrial CV emerged as a significant predictor of AF recurrence, exceeding the predictive significance of atrial voltage. These findings emphasise the importance of considering CV and voltage in managing AF and offer potential insights for personalised strategies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront Cardiovasc Med. 2024 Dec 16:11:1427841pt_PT
dc.identifier.doi10.3389/fcvm.2024.1427841pt_PT
dc.identifier.eissn2297-055X
dc.identifier.urihttp://hdl.handle.net/10400.5/98085
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/journals/cardiovascular-medicinept_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAblationpt_PT
dc.subjectElectrophysiologypt_PT
dc.subjectAtrial conduction velocitypt_PT
dc.subjectAtrial fibrillationpt_PT
dc.subjectAtrial myopathypt_PT
dc.subjectVoltagept_PT
dc.titleThe impact of atrial voltage and conduction velocity phenotypes on atrial fibrillation recurrencept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFrontiers in Cardiovascular Medicinept_PT
oaire.citation.volume11pt_PT
person.familyNameSilva Cunha
person.familyNameMartins Oliveira
person.givenNamePedro Miguel
person.givenNameMario Joao
person.identifier.ciencia-id4716-747F-D64E
person.identifier.ciencia-id2312-2190-19B2
person.identifier.orcid0000-0001-9465-634X
person.identifier.orcid0000-0002-8371-8354
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication77292f94-3ad4-4657-bba0-c54ab9dd641a
relation.isAuthorOfPublication81e0b444-8832-47a8-a911-2f89eb33545d
relation.isAuthorOfPublication.latestForDiscovery81e0b444-8832-47a8-a911-2f89eb33545d

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