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Evaluation of commercial myxomatosis vaccines against recombinant myxoma virus (ha-MYXV) in Iberian hare and wild rabbit

2022-02-24Journal article Open access
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dc.contributor.authorAbade Dos Santos, F.A.
dc.contributor.authorCarvalho, Carina
dc.contributor.authorValente, Pamela
dc.contributor.authorArmes, Henrique
dc.contributor.authorReemers, Sylvia S.
dc.contributor.authorPeleteiro, Maria C.
dc.contributor.authorCalonge Sanz, Ines
dc.contributor.authorDalton, Kevin P.
dc.contributor.authorParra, Francisco
dc.contributor.authorM. Duarte, M. D. Duarte, M. M. Duarte
dc.date.accessioned2022-05-08T22:57:56Z
dc.date.available2022-05-08T22:57:56Z
dc.date.issued2022-02-24
dc.descriptionResearch Areas: Immunology ; Research & Experimental Medicinept_PT
dc.description.abstractThe recent emergence of a new myxoma virus capable of causing disease in the Iberian hare (Lepus granatensis) has resulted in numerous outbreaks with high mortality leading to the reduction, or even the disappearance, of many local populations of this wild species in the Iberian Peninsula. Currently, the available vaccines that prevent myxomatosis in domestic rabbits caused by classic strains of myxoma virus have not been assessed for use in Iberian hares. The main objective of this study was to evaluate the efficacy of commercial rabbit vaccines in Iberian hares and wild rabbits against the natural recombinant myxoma virus (ha-MYXV), bearing in mind its application in specific scenarios where capture is possible, such as genetic reserves. The study used a limited number of animals (pilot study), 15 Iberian hares and 10 wild rabbits. Hares were vaccinated with Mixohipra-FSA vaccine (Hipra) and Mixohipra-H vaccine (Hipra) using two different doses, and rabbits were vaccinated with the Mixohipra-H vaccine or the Nobivac Myxo-RHD PLUS (MSD Animal Health) using the recommended doses for domestic rabbits. After the vaccination trials, the animals were challenged with a wild type strain of ha-MYXV. The results showed that no protection to ha-MYXV challenge was afforded when a commercial dose of Mixohipra-FSA or Mixohipra-H vaccine was used in hares. However, the application of a higher dose of Mixohipra-FSA vaccine may induce protection and could possibly be used to counteract the accelerated decrease of wild hare populations due to ha-MYXV emergence. The two commercial vaccines (Mixohipra-H and Nobivac Myxo-RHD PLUS) tested in wild rabbits were fully protective against ha-MYXV infection. This knowledge gives more insights into ha-MYXV management in hares and rabbits and emphasises the importance of developing a vaccine capable of protecting wild populations of Iberian hare and wild rabbit towards MYXV and ha-MYXV strainspt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAbade dos Santos, FA, Carvalho CL, Valente PCLG, Armés H, Reemers SS, Peleteiro MC, Calonge Sanz I, Dalton KP, Parra F, Duarte MD. 2022. Evaluation of commercial myxomatosis vaccines against recombinant myxoma virus (ha-MYXV) in Iberian hare and wild rabbit. Vaccines, 10(3):356. Doi 10.3390/vaccines10030356pt_PT
dc.identifier.doi10.3390/vaccines10030356pt_PT
dc.identifier.eissn2076-393X
dc.identifier.urihttp://hdl.handle.net/10400.5/24254
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation4757/2017pt_PT
dc.relation2019014300001pt_PT
dc.relationRabbit Viral Haemorrhagic Disease control in Iberian ecosystems: dynamics of virus spread, pathophysiology and improvement of prophylactic measures.
dc.relationCentre for Interdisciplinary Research in Animal Health
dc.relation.publisherversionhttps://www.webofscience.com/wos/woscc/full-record/WOS:000774714300001pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMyxomatosisIberian harept_PT
dc.subjectEuropean wild rabbitpt_PT
dc.subjectvaccinespt_PT
dc.subjectha-MYXVpt_PT
dc.titleEvaluation of commercial myxomatosis vaccines against recombinant myxoma virus (ha-MYXV) in Iberian hare and wild rabbitpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleRabbit Viral Haemorrhagic Disease control in Iberian ecosystems: dynamics of virus spread, pathophysiology and improvement of prophylactic measures.
oaire.awardTitleCentre for Interdisciplinary Research in Animal Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F137067%2F2018/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00276%2F2020/PT
oaire.citation.conferencePlaceBasel, Switzerlandpt_PT
oaire.citation.titleVaccinespt_PT
oaire.citation.volume10(3):356pt_PT
oaire.fundingStreamOE
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAbade dos Santos
person.familyNamePeleteiro
person.familyNameDuarte
person.givenNameFábio
person.givenNameMaria
person.givenNameMargarida
person.identifier.ciencia-idD810-0FEC-8051
person.identifier.ciencia-id6317-1F85-5E59
person.identifier.orcid0000-0002-0696-7322
person.identifier.orcid0000-0003-1848-558X
person.identifier.orcid0000-0003-1488-9659
person.identifier.ridJ-2640-2013
person.identifier.scopus-author-id6602767105
person.identifier.scopus-author-id28267670300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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