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First insights on the susceptibility of native coccidicidal fungi Mucor circinelloides and Mucor lusitanicus to different avian antiparasitic drugs

dc.contributor.authorLozano, João
dc.contributor.authorCunha, Eva
dc.contributor.authorMadeira de Carvalho, Luís
dc.contributor.authorPaz-Silva, Adolfo
dc.contributor.authorOliveira, Manuela
dc.date.accessioned2024-06-29T15:15:24Z
dc.date.available2024-06-29T15:15:24Z
dc.date.issued2024-02-23
dc.descriptionResearch Areas: Veterinary Sciencespt_PT
dc.description.abstractBackground The combined application of predatory fungi and antiparasitic drugs is a sustainable approach for the integrated control of animal gastrointestinal (GI) parasites. However, literature addressing the possible interference of antiparasitic drugs on the performance of these fungi is still scarce. This research aimed to assess the in vitro susceptibility of six native coccidicidal fungi isolates of the species Mucor circinelloides and one Mucor lusitanicus isolate to several antiparasitic drugs commonly used to treat GI parasites’ infections in birds, namely anthelminthics such as Albendazole, Fenbendazole, Levamisole and Ivermectin, and anticoccidials such as Lasalocid, Amprolium and Toltrazuril (drug concentrations of 0.0078–4 µg/mL), using 96-well microplates filled with RPMI 1640 medium, and also on Sabouraud Agar (SA). Results This research revealed that the exposition of all Mucor isolates to the tested anthelminthic and anticoccidial drug concentrations did not inhibit their growth. Fungal growth was recorded in RPMI medium, after 48 h of drug exposure, as well as on SA medium after exposure to the maximum drug concentration. Conclusions Preliminary findings from this research suggest the potential compatibility of these Mucor isolates with antiparasitic drugs for the integrated control of avian intestinal parasites. However, further in vitro and in vivo studies are needed to confirm this hypothesis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLozano J, Cunha E, de Carvalho LM, Paz-Silva A, Oliveira M. 2024. First insights on the susceptibility of native coccidicidal fungi Mucor circinelloides and Mucor lusitanicus to different avian antiparasitic drugs. BMC Veterinary Research, 20(1):63. doi: 10.1186/s12917-024-03909-zpt_PT
dc.identifier.doi10.1186/s12917-024-03909-zpt_PT
dc.identifier.eissn1746-6148
dc.identifier.urihttp://hdl.handle.net/10400.5/31194
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMCpt_PT
dc.relationED431B 2021/07pt_PT
dc.relationCentre for Interdisciplinary Research in Animal Health
dc.relationAssociate Laboratory for Animal and Veterinary Sciences
dc.relationNovo: Integrated control of avian gastrointestinal parasites: optimizing their coprological diagnosis and biocontrol using predatory fungi. Inicial: Gastrointestinal Parasites of Domestic Birds and their Biological Control with Predatory Fungi
dc.relation.publisherversionhttps://bmcvetres.biomedcentral.com/articles/10.1186/s12917-024-03909-zpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectGastrointestinal parasitespt_PT
dc.subjectPredatory fungipt_PT
dc.subjectMucor spp.pt_PT
dc.subjectAntiparasitic drugspt_PT
dc.subjectSusceptibilitypt_PT
dc.titleFirst insights on the susceptibility of native coccidicidal fungi Mucor circinelloides and Mucor lusitanicus to different avian antiparasitic drugspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Interdisciplinary Research in Animal Health
oaire.awardTitleAssociate Laboratory for Animal and Veterinary Sciences
oaire.awardTitleNovo: Integrated control of avian gastrointestinal parasites: optimizing their coprological diagnosis and biocontrol using predatory fungi. Inicial: Gastrointestinal Parasites of Domestic Birds and their Biological Control with Predatory Fungi
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00276%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0059%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/2020.09037.BD/PT
oaire.citation.conferencePlaceLondon, Englandpt_PT
oaire.citation.issue1pt_PT
oaire.citation.titleBMC Veterinary Researchpt_PT
oaire.citation.volume20pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamOE
person.familyNamePestana Lozano
person.familyNameGonçalves da Cunha
person.familyNameMadeira de Carvalho
person.familyNameOliveira
person.givenNameJoão Miguel
person.givenNameEva Sofia
person.givenNameLuís Manuel
person.givenNameManuela
person.identifier.ciencia-idA81D-BFE3-3D35
person.identifier.ciencia-id9811-7B6B-E2B9
person.identifier.ciencia-id9416-643A-4E0C
person.identifier.ciencia-idBE1E-2B3B-92D2
person.identifier.orcid0000-0001-5390-6998
person.identifier.orcid0000-0002-5641-4400
person.identifier.orcid0000-0002-7548-667X
person.identifier.orcid0000-0002-3910-1525
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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