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Hypothalamic Ion channels in hypertension

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dc.contributor.authorGeraldes, Vera
dc.contributor.authorLaranjo, Sergio
dc.contributor.authorRocha, Isabel
dc.date.accessioned2019-07-16T14:27:26Z
dc.date.available2019-07-16T14:27:26Z
dc.date.issued2018
dc.description©Springer Science+Business Media, LLC, part of Springer Nature 2018pt_PT
dc.description.abstractHypertension is a prevalent and major health problem, involving a complex integration of different organ systems, including the central nervous system (CNS). The CNS and the hypothalamus in particular are intricately involved in the pathogenesis of hypertension. In fact, evidence supports altered hypothalamic neuronal activity as a major factor contributing to increased sympathetic drive and increased blood pressure. Several mechanisms have been proposed to contribute to hypothalamic-driven sympathetic activity, including altered ion channel function. Ion channels are critical regulators of neuronal excitability and synaptic function in the brain and, thus, important for blood pressure homeostasis regulation. These include sodium channels, voltage-gated calcium channels, and potassium channels being some of them already identified in hypothalamic neurons. This brief review summarizes the hypothalamic ion channels that may be involved in hypertension, highlighting recent findings that suggest that hypothalamic ion channel modulation can affect the central control of blood pressure and, therefore, suggesting future development of interventional strategies designed to treat hypertension.pt_PT
dc.description.sponsorshipDr. Rocha reports a grant from Portuguese Foundation for Science and Technology [2010–2013–FCT/PTDC/SAUOSM/109081/2008].pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCurr Hypertens Rep (2018) 20: 14pt_PT
dc.identifier.doi10.1007/s11906-018-0814-xpt_PT
dc.identifier.issn1522-6417
dc.identifier.urihttp://hdl.handle.net/10451/39134
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/journal/11906pt_PT
dc.subjectHypothalamuspt_PT
dc.subjectIon channelspt_PT
dc.subjectHypertensionpt_PT
dc.subjectSympathetic nervous systempt_PT
dc.subjectSodium channelspt_PT
dc.subjectPotassium channelspt_PT
dc.subjectCalcium channelspt_PT
dc.titleHypothalamic Ion channels in hypertensionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPTDC/SAU-OSM/109081/2008
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-OSM%2F109081%2F2008/PT
oaire.citation.issue2pt_PT
oaire.citation.startPage14pt_PT
oaire.citation.titleCurrent Hypertension Reportspt_PT
oaire.citation.volume20pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameGeraldes
person.familyNameLaranjo
person.givenNameVera
person.givenNameSergio
person.identifier36332
person.identifier.ciencia-idD51D-E96C-1633
person.identifier.ciencia-id351B-92E1-0C50
person.identifier.orcid0000-0003-1275-3459
person.identifier.orcid0000-0003-2169-4024
person.identifier.ridM-4137-2013
person.identifier.ridG-2909-2011
person.identifier.scopus-author-id24391148400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication16b49724-d060-4106-955d-d211cba44c12
relation.isAuthorOfPublication902d64d7-c6bf-4b05-8f49-3b52dd0aa452
relation.isAuthorOfPublication.latestForDiscovery902d64d7-c6bf-4b05-8f49-3b52dd0aa452
relation.isProjectOfPublication50644c7b-0bf1-4559-a75b-81b4dad69bcb
relation.isProjectOfPublication.latestForDiscovery50644c7b-0bf1-4559-a75b-81b4dad69bcb

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