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On the progress of hydrogel-based 3D printing: Correlating rheological properties with printing behaviour

2022-03Journal article Open access
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dc.contributor.authorBom, Sara
dc.contributor.authorRibeiro, Ricardo
dc.contributor.authorRibeiro, Helena
dc.contributor.authorSantos, Catarina
dc.contributor.authorMarto, Joana
dc.date.accessioned2023-08-17T14:55:55Z
dc.date.available2023-08-17T14:55:55Z
dc.date.issued2022-03
dc.date.updated2022-12-17T15:52:47Z
dc.description.abstractOne of the exciting future directions in the 3D printing field is the development of innovative personalized smart constructions for bio-applications, including drug delivery, namely high-throughput drug screening and customized topical/oral administration of pharmaceuticals, as well as tissue engineering. In this context, hydrogels have emerged as a promising material that, when combined with extrusion 3D printing, allow the creation of soft-material structures with defined spatial locations, that can be printed at room temperature and customized by tuning the geometric design and/or the formulation components. Thus, the efficacy and quality of such vehicles is dependent on formulation, design, and printing process parameters. However, hydrogel inks are often designed and characterized using different methods and this lack of uniformity impairs. Characterization techniques are usually arbitrary and differ among research groups, challenging the inference of possible conclusions on hydrogel behaviour and potential applications. Therefore, to properly analyse the potential of a particular hydrogel ink formulation, we review, for the first time, the most frequently employed characterization procedures, from rheological approaches to printing parameters and settings, and discuss their relevance, limitations and drawbacks, and highlight future perspectives. Overall, to accelerate the development of high-quality 3D constructs, comprehensive characterization protocols for both pre-printing and printing assays should be adopted. Furthermore, their transversal adoption could serve as a boost in terms of quality requirements and regulatory aspects.pt_PT
dc.description.sponsorshipThis research was funded by the Fundação para a Ciência e Tecnologia, Portugal (UIDB/04138/2020 and UIDP/04138/2020 to iMed.ULisboa, PTDC/MEC-DER/30198/2017 and CEECINST/00145/2018 to J.Marto, and CQE UIDB/QUI/00100/2020 to C.Santos. S.Bom was supported by a PhD fellowship (3DGelComp project) from Instituto Politécnico de Setubal.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBom S, Ribeiro R, Ribeiro HM, Santos C, Marto J. On the progress of hydrogel-based 3D printing: Correlating rheological properties with printing behaviour. International Journal of Pharmaceutics [Internet]. 5 de março de 2022;615:121506. Disponível em: https://www.sciencedirect.com/science/article/pii/S037851732200059Xpt_PT
dc.identifier.doi10.1016/j.ijpharm.2022.121506pt_PT
dc.identifier.issn0378-5173
dc.identifier.slugcv-prod-2851890
dc.identifier.urihttp://hdl.handle.net/10451/58913
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationUIDB/QUI/00100/2020pt_PT
dc.relationResearch Institute for Medicines
dc.relationResearch Institute for Medicines
dc.relationSerotonergic-based therapies to decrease the impact of moderate to severe psoriasis: translation of fundamental research into industry
dc.relationNot Available
dc.relationNot Available
dc.relationNot Available
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S037851732200059Xpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPrintabilitypt_PT
dc.subjectExtrudabilitypt_PT
dc.subjectPrinting accuracypt_PT
dc.subjectShape fidelitypt_PT
dc.subjectPrinting precisionpt_PT
dc.titleOn the progress of hydrogel-based 3D printing: Correlating rheological properties with printing behaviourpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleSerotonergic-based therapies to decrease the impact of moderate to severe psoriasis: translation of fundamental research into industry
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMEC-DER%2F30198%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00145%2F2018%2FCP1571%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00145%2F2018%2FCP1571%2FCT0002/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00145%2F2018%2FCP1571%2FCT0003/PT
oaire.citation.startPage121506pt_PT
oaire.citation.titleInternational Journal of Pharmaceuticspt_PT
oaire.citation.volume615pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStreamCEEC INST 2018
oaire.fundingStreamCEEC INST 2018
oaire.fundingStreamCEEC INST 2018
person.familyNameBom
person.familyNameRibeiro
person.familyNameMarques Marto
person.givenNameSara
person.givenNameHelena
person.givenNameJoana
person.identifier1570599
person.identifier.ciencia-id161F-B79B-D660
person.identifier.ciencia-id891B-12E1-C2BF
person.identifier.orcid0000-0002-6990-1208
person.identifier.orcid0000-0002-2429-7991
person.identifier.orcid0000-0001-5523-5622
person.identifier.ridE-2944-2015
person.identifier.scopus-author-id35896704400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid891B-12E1-C2BF | Joana Marques Marto
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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