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Matrix Metalloproteinase-9 levels are associated with brain lesion and persistent venous occlusion in patients with cerebral venous thrombosis

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dc.contributor.authorde Sousa, Diana Aguiar
dc.contributor.authorPereira Santos, Maria Conceição
dc.contributor.authorSerra-Caetano, Ana
dc.contributor.authorLucas Neto, Lia
dc.contributor.authorSousa, Ana Luísa
dc.contributor.authorGabriel, Denis
dc.contributor.authorCorreia, Manuel
dc.contributor.authorGil-Gouveia, Raquel
dc.contributor.authorOliveira, Renato
dc.contributor.authorPenas, Sara
dc.contributor.authorCarvalho Dias, Mariana
dc.contributor.authorCorreia, Manuel A.
dc.contributor.authorCarvalho, Marta
dc.contributor.authorSousa, Ana E.
dc.contributor.authorCanhão, Patrícia
dc.contributor.authorFerro, José
dc.date.accessioned2021-12-03T16:50:06Z
dc.date.available2021-12-03T16:50:06Z
dc.date.issued2021
dc.description© 2021 Thieme. All rights reserved.pt_PT
dc.description.abstractBackground: Elucidating mechanisms of brain damage in cerebral venous thrombosis (CVT) would be instrumental to develop targeted therapies and improve prognosis prediction. Matrix metalloproteinase-9 (MMP-9), a gelatinase that degrades major components of the basal lamina, has been associated to blood-brain barrier disruption. We aimed to assess, in patients with CVT, the temporal change in serum concentrations of MMP-9 and its association with key imaging and clinical outcomes. Methods: Pathophysiology of Venous Infarction-PRediction of InfarctiOn and RecanalIzaTion in CVT (PRIORITy-CVT) was a multicenter prospective cohort study of patients with newly diagnosed CVT. Serial collection of peripheral blood samples performed on day 1, 3, and 8, and standardized magnetic resonance imaging on day 1, 8, and 90. MMP-9 was quantified using enzyme-linked immunosorbent assay in 59 patients and 22 healthy controls. Primary outcomes were parenchymal brain lesion, early evolution of brain lesion, early recanalization, and functional outcome on day 90. Results: CVT patients with parenchymal brain lesion had higher baseline concentrations of MMP-9 compared with controls (adjusted p = 0.001). The area under receiver operating characteristic curve value for MMP-9 for predicting brain lesion was 0.71 (95% confidence interval [CI]: 0.57-0.85, p = 0.009). Patients with venous recanalization showed early decline of circulating MMP-9 and significantly lower levels on day 8 (p = 0.021). Higher MMP-9 on day 8 was associated with persistent venous occlusion (odds ratio: 1.20 [per 20 ng/mL], 95% CI: 1.02-1.43, p = 0.030). Conclusion: We report a novel relationship among MMP-9, parenchymal brain damage, and early venous recanalization, suggesting that circulating MMP-9 is a dynamic marker of brain tissue damage in patients with CVT.pt_PT
dc.description.sponsorshipThis study was supported by 11° Bolsa de Investigação Fundação AstraZeneca - Faculdade de Medicina Universidade de Lisboa, D. Manuel de Mello grant, and Fundação Amélia de Mello. D.A.S. was supported by a doctoral grant SFRH/SINTD/92677/2013 from Fundação para Ciência e Tecnologia.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationThromb Haemost. 2021 Nov;121(11):1476-1482pt_PT
dc.identifier.doi10.1055/s-0041-1726094pt_PT
dc.identifier.eissn2567-689X
dc.identifier.issn0340-6245
dc.identifier.urihttp://hdl.handle.net/10451/50276
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherThiemept_PT
dc.relationTROMBOSE VENOSA CELEBRAL: DA FISIOPATOLOGIA À TERAPÊUTICA
dc.relation.publisherversionhttps://www.thieme-connect.de/products/ejournals/issue/eFirst/10.1055/s-00035024pt_PT
dc.subjectCerebral venous thrombosispt_PT
dc.subjectBlood–brain barrierpt_PT
dc.subjectInfarctionpt_PT
dc.subjectRecanalizationpt_PT
dc.subjectPrognosispt_PT
dc.titleMatrix Metalloproteinase-9 levels are associated with brain lesion and persistent venous occlusion in patients with cerebral venous thrombosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberSFRH/SINTD/92677/2013
oaire.awardTitleTROMBOSE VENOSA CELEBRAL: DA FISIOPATOLOGIA À TERAPÊUTICA
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FSINTD%2F92677%2F2013/PT
oaire.citation.endPage1482pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage1476pt_PT
oaire.citation.titleThrombosis and Haemostasispt_PT
oaire.citation.volume121pt_PT
person.familyNameAguiar de Sousa
person.familyNameCaetano
person.familyNameLucas Neto
person.familyNameGil-Gouveia
person.familyNameOliveira
person.familyNameCarvalho Dias
person.familyNameAmorim Correia
person.familyNameCarvalho
person.familyNameSousa
person.familyNameCanhão
person.familyNameMorão Cabral Ferro
person.givenNameDiana
person.givenNameAna
person.givenNameLia
person.givenNameRaquel
person.givenNameRenato
person.givenNameMariana
person.givenNameManuel Alberto
person.givenNameMarta
person.givenNameAna E.
person.givenNamePatrícia
person.givenNameJosé Manuel
person.identifier574112
person.identifier389864
person.identifier61187
person.identifier.ciencia-id571C-121A-5CCB
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person.identifier.ciencia-idD311-4BED-A52B
person.identifier.ciencia-idD015-D3A2-992D
person.identifier.ciencia-id8F12-6A40-BE2E
person.identifier.ciencia-id6F16-7E25-7AAF
person.identifier.orcid0000-0002-6702-7924
person.identifier.orcid0000-0002-1626-4364
person.identifier.orcid0000-0001-7880-9625
person.identifier.orcid0000-0002-4256-4256
person.identifier.orcid0000-0003-1181-1418
person.identifier.orcid0000-0002-6603-1796
person.identifier.orcid0000-0002-3102-9389
person.identifier.orcid0000-0002-6323-8599
person.identifier.orcid0000-0002-4618-9799
person.identifier.orcid0000-0003-3816-0416
person.identifier.orcid0000-0002-2343-9097
person.identifier.ridJ-4105-2013
person.identifier.ridL-2642-2014
person.identifier.scopus-author-id55781226000
person.identifier.scopus-author-id7202484563
person.identifier.scopus-author-id6603685711
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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