Red blood cell-pancreatic cancer hybrid membrane-camouflaged vitamin E derivatives-based nanoparticles for homotypic targeted co-delivery of paclitaxel and gemcitabine to fight pancreatic cancer

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Nanotechnology-based sunscreens - a review

Publication . Paiva-Santos, Ana Cláudia; Marto, Joana; Chá-Chá, R.; Martins, Ana M.; Pereira-Silva, M.; Ribeiro, Helena; Veiga, F.

The daily use of sun protection is essential to prevent the damaging effect of incident solar ultraviolet (UV) radiation. Sunscreens are cosmetic products containing UV filters as active compounds, which are responsible for the absorption and/or reflection of UV radiation that might otherwise reach the skin surface. Sunscreen formulation has undergone a major technological transformation over the recent past, resulting in improved sunscreen efficiency and safety. In this context, nanosystems have emerged as suitable carriers of UV filters, originating from the so-called nanosunscreens. The aim of the present review is to provide a conceptual framework based on several nanosystems at the forefront of these advances, including nanoemulsions, liposomes and ultradeformable vesicles (transfersomes, ethosomes, and transethosomes), solid lipid nanoparticles, nanostructured lipid carriers, polymeric nanoparticles, mesoporous silica nanoparticles, nanocrystals, and SunSpheres. Moreover, the beneficial effects these nanosystems impart to typical formulations are described. Finally, the potential impacts of these nanosystems on human health are discussed, and regulatory approaches by administrations around the globe are reviewed.

2022-03Artigo científico

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Nanomaterials in hair care and treatment

Publication . Pereira-Silva, Miguel; Martins, Ana; Sousa-Oliveira, Inês; Ribeiro, Helena; Veiga, Francisco; Marto, Joana; Cláudia Paiva-Santos, Ana

Hair care and treatment has evolved significantly through the years as new formulations are continuously being explored in an attempt to meet the demand in cosmetic and medicinal fields. While standard hair care procedures include hair washing, aimed at hair cleansing and maintenance, as well as hair dyeing and bleaching formulations for hair embellishment, modern hair treatments are mainly focused on circumventing hair loss conditions, strengthening hair follicle properties and treat hair infestations. In this regard, active compounds (ACs) included in hair cosmetic formulations include a vast array of hair cleansing and hair dye molecules, and typical hair treatments include anti-hair loss ACs (e.g. minoxidil and finasteride) and anti-lice ACs (e.g. permethrin). However, several challenges still persist, as conventional AC formulations exhibit sub-optimal performance and some may present toxicity issues, calling for an improved design of formulations regarding both efficacy and safety. More recently, nano-based strategies encompassing nanomaterials have emerged as promising tailored approaches to improve the performance of ACs incorporated into hair cosmetics and treatment formulations. The interest in using these nanomaterials is based on account of their ability to: (1) increase stability, safety and biocompatibility of ACs; (2) maximize hair affinity, contact and retention, acting as versatile biointerfaces; (3) enable the controlled release of ACs in both hair and scalp, serving as prolonged AC reservoirs; besides offering (4) hair follicle targeting features attending to the possibility of surface tunability. This review covers the breakthrough of nanomaterials for hair cosmetics and hair treatment, focusing on organic nanomaterials (polymer-based and lipid-based nanoparticles) and inorganic nanomaterials (nanosheets, nanotubes and inorganic nanoparticles), as well as their applications, highlighting their potential as innovative multifunctional nanomaterials towards maximized hair care and treatment. Statement of significance This manuscript is focused on reviewing the nanotechnological strategies investigated for hair care and treatment so far. While conventional formulations exhibit sub-optimal performance and some may present toxicity issues, the selection of improved and suitable nanodelivery systems is of utmost relevance to ensure a proper active ingredient release in both hair and scalp, maximize hair affinity, contact and retention, and provide hair follicle targeting features, warranting stability, efficacy and safety. This innovative manuscript highlights the advantages of nanotechnology-based approaches, particularly as tunable and versatile biointerfaces, and their applications as innovative multifunctional nanomaterials towards maximized hair care and treatment.

2022-02Artigo científico

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Fundação para a Ciência e a Tecnologia

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SFRH/BD/148771/2019