Publication . Excofffier, Laurent; Marchi, Nina; Marques, David Alexander; Matthey-Doret, Remi; Gouy, Alexandre; Sousa, Vitor C
fastsimcoal2 is a continuous time coalescent-based genetic simulation program. It extends fastsimcoal by enabling the estimation of demographic parameters under very complex scenarios from the site frequency spectrum under a maximum-likelihood framework. Other improvements include multi-threading, handling of population inbreeding, extended input file syntax facilitating the description of complex demographic scenarios, and more efficient simulations of sparsely structured populations and of large chromosomes.