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- Acute phase proteins in catsPublication . Rosa, Rita Mourão; Mestrinho, Lisa Alexandra PereiraAcute phase proteins (APP) are proteins synthesized and released largely by hepatocytes upon the occurrence of cell damage or invasion by microorganisms. This article reviews the use of APP in feline diseases, identifying their usefulness in the clinical setting, analyzing 55 published papers. Serum amyloid A, alpha-1 acid glycoprotein, and haptoglobin are the indicators pointed out by the authors as useful in monitoring the acute inflammatory response in cats. Although, APP measurement is still not routinely used in veterinary medicine, together with clinical signs and other blood parameters, was of clinical interest and applicability in diseases such as feline infectious peritonitis, pancreatitis, renal failure, retroviral and Calicivirus infections. Although, there are commercially available kits for dosing feline APP, assay standardization aiming technical simplicity, more species specificity and with less associated costs will allow routine use in feline practice, as it is done in the human field.
- Surgical excision of an adrenal neuroblastoma in a dogPublication . Mestrinho, Lisa Alexandra Pereira; Marques, Maria Inês; Jesus, Sandra; Pissarra, Hugo; Peleteiro, Maria C.; Ferreira, AntónioABSTRACT - A 11-month-old, intact male, Rhodesian Ridgeback was presented to the Veterinary Teaching Hospital with signs of inappetence, lethargy, and abdominal pain for 3 days. A large and well-defined abdominal retroperitoneal mass, related with the left kidney, at the expected location of the adrenal gland, was revealed by radiography, ultrasound, and computed tomography. The mass extended caudally to the iliac artery bifurcation, compressing the aorta, caudal vena cava, and both kidneys. Cytology findings were compatible with a malignant round cell tumor. The most probable diagnosis was neuroblastoma. Following a comprehensive discussion with the owners about a treatment plan, surgical excision was performed. Because a wide excision would compromise major vessels, excision was performed after careful dissection of the aorta and vena cava. The left kidney was removed because the proximal ureter could not be separated from the tumor. The animal recovered successfully. Diagnosis was confirmed by histopathology and immunohistochemistry, but the owners decided not to pursue any further treatment. Clinical signs of abdominal pain recurred within 1 month following surgery. Therefore, the animal was euthanized upon the owners' request. This report describes the diagnosis, surgical treatment, and follow-up of a dog with an abdominal peripheral neuroblastoma.
- Retrospective study of 18 titanium alloy crowns produced by computer-aided design and manufacturing in dogsPublication . Mestrinho, Lisa Alexandra Pereira; Gordo, Inês; Gawor, Jerzy; Leal, Nuno; Niza, MariaABSTRACT - Computer-aided design (CAD) and computer-aided manufacturing (CAM) technology is routinely used in various fields of human dentistry, particularly prosthodontics. Reverse engineering and additive manufacturing allow the technician to create an easier, faster and more accurate restoration, with a natural design and adequate strength. Eighteen titanium alloy full crowns were produced for canine teeth of 7 working dogs using CAD/CAM technology (3D BioCare, Nobel Biocare). Reasons for crown therapy included abrasion, enamel infraction, and crown fracture. Crown preparation was routinely performed, and impressions were delivered to the laboratory where digital impressions were performed with a lab scanner. Using 3D dental design software, the metal crown was designed and sent for manufacture. Each prosthodontic crown was then carved from a solid titanium alloy block to obtain the final crown. All prosthodontic crowns were an adequate fit, and cementation was routinely performed. Crowns were lost from 2 canine teeth during the dogs' normal working activity, in one case, for 2 times. In all cases, replicas were requested. In the first case, the second cementation was successful. In the second case, the second crown was again lost and only the third cementation was successful. Follow up of all cases range from 12 to 62 months. Mean survival time for the crowns was 58.0 months. Here, CAD/CAM technology is shown to be a useful tool for manufacturing accurate prosthodontic crowns for veterinary patients. Moreover, CAD/CAM enables the production of prosthodontic crown replicas in a very short time and at relatively low cost compared to traditional methods, consequently eliminating the need for at least one anesthetic procedure in the incidence of crown cementation failure.