Browsing by Author "Ruiter, Jos P. N."
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- Studies on the extra-mitochondrial CoA-ester formation of valproic and Delta(4)-valproic acidsPublication . Aires, Catia C. P.; Ruiter, Jos P. N.; Luis, Paula B. M.; ten Brink, Herman J.; Ijlst, Lodewijk; de Almeida, Isabel Tavares; Duran, Marinus; Wanders, Ronald J. A.; Silva, Margarida F. B.The hypothesis whether valproic acid (VPA) and its main microsomal metabolite, Delta(4) -valproic acid, can be activated to the respective CoA esters in the cell cytosol was investigated. The valproyl-CoA formation was measured in different subcellular fr
- Valproic acid metabolites inhibit dihydrolipoyl dehydrogenase activity leading to impaired 2-oxoglutarate-driven oxidative phosphorylationPublication . Luis, Paula B. M.; Ruiter, Jos P. N.; Aires, Catia C. P.; Soveral, Graca; de Almelda, Isabel Tavares; Duran, Marinus; Wanders, Ronald J. A.; Silva, Margarida F. B.The effect of the antiepileptic drug valproic acid (VPA) on mitochondrial oxidative phosphorylation (OXPHOS) was investigated in vitro. Two experimental approaches were used, in the presence of selected respiratory-chain Substrates: (1) formation of ATP i