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Browsing by Author "Rodrigues, Vasco"

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  • Takeover bids : evidence from the Portuguese market
    Publication . Rodrigues, Vasco
    Throughout the nineties, a number of tender offers occurred in the Por- tuguese market. This article employs event study methodology to investigate their effects on the involved firms’ shareholders. On average, these operations increased the market value of the involved firms by 2% to 3%. However, target sharehold- ers appropriated most of this gain, earning 18% over their firms’ previous value, whereas bidder shareholders seem to have gained nothing. These averages bent in bidders shareholders favour, however, when bidders held significant positions in the targets’ capital before the bid.
    2003-12Journal article Restricted access Show more
  • Variation in type of adjuvant chemotherapy received among patients with stage I breast cancer: a multi-institutional Portuguese cohort study
    Publication . Ferreira, Arlindo; Palha, Ana; Correia, Lurdes; Filipe, Pedro; Rodrigues, Vasco; Costa, Luis; Miranda, Ana; André, Rosário; Fernandes, João; Gouveia, Joaquim; Passos-Coelho, José Luís; Moreira, António; Brito, Margarida; Ribeiro, Joana; Metzger-Filho, Otto; U. Lin, Nancy; Vaz-Luís, Inês
    Background: A contemporary US study showed an increase in the use of chemotherapy in the last decade for some patients with stage-I breast cancer; with a rise in more intensive regimens, and declining use of anthracyclines. Nevertheless, there is still uncertainty on the absolute benefit of chemotherapy for these patients and the optimal regimen. In this study we compare those findings with the patterns of care among a Portuguese cohort of stage-I breast cancers. Methods: Retrospective cohort study of patients with stage-I breast cancer diagnosed from 2006 to 2008 at four Portuguese institutions. The use and type of chemotherapy was evaluated. Results: Among patients with stage I-III breast cancer 39.4% (n = 682) had stage I disease. Of the 595 eligible patients, 22.4% were treated with chemotherapy, 33.9% aged <55 years vs. 12.7% aged >65 years (p < 0.001). Thirteen percent of patients with hormone receptor (HR)+/HER2- tumors, 52.7% of patients with HER2+ and 66.0% of patients with HR-/HER2- received chemotherapy (p < 0.001). In addition, we found inter-institutional variability, with the use of chemotherapy ranging from 0.0% to 43.4% (p < 0.001). Eighty-five percent of patients treated with chemotherapy received less-intensive regimens with anthracycline-based regimens, such as doxorubicin and cyclophosphamide, being the most frequently used, while docetaxel and cyclophosphamide was only used in 1.5% of cases. Conclusions: Overall, almost one-quarter of patients received chemotherapy with institutional variability. When treated, mostly less-intensive associations including anthracyclines were used, which contrasts with contemporary US practice. This study highlights the need for health-services research to understand local practices and tailor quality improvement interventions.
    2016Journal article Restricted access Show more